三维适形放疗中呼吸运动对肺肿瘤的剂量分布影响

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1、中文摘要关键词：三维适形放疗；呼吸运动；肺肿瘤；靶区剂量分布；内边界(IM)英文摘要Dosimetricinfluenceoflungtumorforrespiratorymovementinthreedimensionalconformalradiationtherapy(3DCRT)ABSTRACTobjective：ThreedimensionalconforlTlalradiationtherapy(3DCRT)isapreciseadvancedradiotherapytechnique，whichcan

2、elevatedoseoftargettumoranddecreaseextentofnormaltissue．Becausethetechniqueneedratherconformalrequest，itneedhigh—precisiontargetlocation．Respiratorymovementwouldmostlydepresstreatmentefficacyforlungcancerby3DCRT．Forcounteractingtheeffect，usuallyaddmarginfromCT

3、VtoPTVtoensuenottoleaktumor．ThemarginintheICRU62reportiscalledinternalmargin(IM)．Nowthemarginaltitudehasnotfinalconclusion，SOmostthinktumormovementaltitudebysimulationequipmentisoutsidemargin．But，wealwaysthinkifpracticaldosedistribution(emphasistoconsider90％is

4、odosedistribution)fortargetmovementconcord3Dmotionattitudeoftumorfromsimulationequipment．Tostudydosimetricinfluenceofdifferentsizelungcancerforrespiratorymovementin3D—RT,forexactlyunderstandingclinicalrealdosedistributionandprovidingdosimetric‘nfitionfordefini

5、tionIMto[；ateintormationtbcomoensaterrespiratorymovement．Methods：Motionphantomsystemwasusedtosimulate气英文摘要normalrespiratorymovementwithsimilarmotioncondition(motionamplitude15mm，motionfrequency21／minute)，whichcansimulatetargettumormovementalongZaxle．ByCMStreat

6、mentplansygtemwedefaultthreerectanglesimulationtumortarget，whichsizesare2×2cm，5×5cmand8×8cm．TPSrequest：1．isocenterradiationfor3cm；2．simulatetumortargetcontainedby90％isodose，whichrequest98％comfortbalinspection；3．tosupposenopositionerror；4．tousesinglenearingfiel

7、d．ByCMStreatmentplansystemweworkouteveryirradiationfieldandtransmittoacceleratorbynetwork．Thenweworkoutexpandingirradiationfield，whichrequestexpandingO．5cm，1．0cm，1．5cmalongmotordirectionforretrievemotioneffectandnotexpandingatverticalmotordirection．WeputKodak—

8、omatfilmunder3．0cmdepth．isocenterirradiateeveryfieldin300MU／minand100cGy／Fat0gantryangle．InquiescentconditioneveryfieldirradiatethreetimesandInmotionconditioneveryfieldirradiatethr