可转形穴位注射药对脑缺血再灌注大鼠皮质区vegf、bfgf的影响

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1、关键词可转形穴位注射药；脑缺血再灌注；大椎、内关；血管内皮生长因子(VEGF)；碱性成纤维生长因子(bFGF)课题来源：湖北省自然科学基金项目(No．20090DB417)TheEffectofDeformabIeEmbeddingMedicaredInjectionThreadinAcupointsonBrainTissueVEGFandbFGFofRatsWithFocaICerebraIschemiaReperfusionInjurySpeciaIty：AcupunctureandMoxibustionAutor：HuWeijingTutor：PrefessorKongLihongAbs

2、tractObjectivesprojectbyLigustrazineasmodeldrug，thecerebralischemiareperfusionrats，DazhuiandNeiguanthetreatmentofacupointembeddingcanturnacupointinjectionofdrug1ine，andburiedtheLigustrazinecollagendrug1inewiththesameacupointScatgutand1igustrazinedrugscompared．ThebiodegradablepolymermaterialS，theprep

3、arationofLigustrazineintosuitabletransformationpointinjectiontherapy，themedicine1inehavingatroomtemperature1iquid，semi—S01idgelformingpropertiesofinvivo．CerebralCOTtexofvascularendothelialgrowthfactorinratswereobservedbyimmunohiStochemiStryaftertreatment(VEGF)andbasicfibroblastgrowthfactot(bFGF)expr

4、esSionof．．NethodsInthiStudy，referringtotheexperimenta1Studies，USingorthogonaldesignmethod，thechitosanmixture，twopotasSiumhydrogenphosphateanhydrousand1igustrazinearemixedincertainproportionandpreparedintocanturnpointinjectiontherapy，themedicineonthewireintotheexperimentalanimalpointaftertheabsorptio

5、nspeedandsafetyandtheexperimentalanimalcerebralcortexvaSCUlarendothelialgrowthfactor(VEGF)andbasicfibroblastgrowthfactor(bFGF)IVexpresSionof．(1)experimenta1StudyonitSabsorptionrate，hea1thySDratSwereselected，randomlydividedintoLigustrazineCOllagendruggroup，ligustrazinedrugmulegroup，canturnacupointinj

6、ectiontherapygroup，thesamelengthofLigustrazinecollagendrug1ine2mmandsoakedin1igustrazineinjectiontechnique2mm，medicationdosemayturnpointinjectiondrug1ine(2ml：4mg)0．1mlimplantation，Neiguanpointdazhui．In3days，5days，7daysaftertheacupointanatomy，ligustrazinecol1agendrug1ine，nakedeyeobservationLigustrazi

7、nemediCinalcatgut，canturnpointinjectiondrug1ineinratacupointabsorptionlosSof．(2)fortheexperimentalStudyoftheirsafety，thefirstselectionofhealthyguineapigs，acertainamountoftransformationpointinjectiondr