脑缺血再灌注损伤对羟基红花黄色素a透过血脑屏障的分析

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1、山东大学硕士学位论文Results(1)Thebrainsoftheshamgroupshowed110grosslyvisibleareasofEBextravasation．TheEBcontentofbrainobviouslyincreasedintheipsilateralcerebrumcompared而thshamgroupaftercerebralischemiareperfusion3h，subsequentlyitcontinuedincreasingonreperfusion24h．(2)Lo

2、werconcentrationofhydroxysaffloryellowAcouldbedetectedincontrolgroupafterl0to60minadministration．TherewerenosignificantdifferencebetweentheshamgroupsandthecontrolgroupinHSYAconcentrationinbraintissue．TheHSYAconcentrationinischemichemisphereofischemia／reperfusi

3、onratssignificantlyincreased，whiledidnotchangeinnon—ischemichemispherecompared、航thshamgroup．(3)MMP一9werenotdetectedinthebrainofshamgroupandsham(HSYA)group．ThelevelofMMP-9expressioninischemia／reperfusionandischemia／reperfusion(HSYA)groupsobviouslyincreasedcompa

4、red、)~，itllshamgroupandsham(HSYA)grouprespectively．Therewasnosignificantdifferencebetweenisehemia／reperfusionandischemia／reperfusion(HSYA)group．ConelusionBBBpermeabilityincreasedwhichencounteredCIRI．HSYAcanpenetratetheBBBtoreachthebraintissuewithlowpenetration

5、inphysiologiccondition，andtheBBBpenetrationofHSYAisincreasedobviouslyafterCIRI，paralledwithBBBpermeability．IncreasedBBBpenetrationofHSYAwhichencounteredcerebralischemiamayhaverelationwithitslevelofMMP一9expression．Keywords：HydroxysaffloryellowA；Cerebralischemia

6、／reperfusion；Blood．brainbarrier；EvansBlue；HPLC；Matrixmetalloproteinase·95山东大学硕士学位论文英文缩略英文全称TJBBBBCECsCCAIRCNSEBECAICAHSYAz．p．MCAMCAOMMPsMMP．9NSODtightjunctionblood．brainbarrier符号说明中文全称紧密连接血脑屏障braincapillaryendothelialcells脑毛细血管内皮细胞commoncarotidartery颈总动脉cerebr

7、alischemia／reperfusioninjury脑缺血再灌注损伤centralnervoussystemevansblue中枢神经系统伊文思蓝externalcarotidartery颈外动脉internalcarotidartery颈内动脉hydroxysaffioryellowAintraperitonealinjection羟基红花黄色素A腹腔注射middlecerebralartery大脑中动脉middlecerebralarteryocclusion大脑中动脉阻塞matrixMetalloprot

8、einases基质金属蛋白酶matrixMetalloproteinase-9基质金属蛋白酶．9normalsalineopticaldentisy生理盐水吸光度6山东大学硕士学位论文原创性声明本人郑重声明：所呈交的学位论文，是本人在导师的指导下，独立进行研究所取得的成果。除文中已经注明引用的内容外，本论文不包含任何其他个人或集体已经发表或撰写过的科研成果。