egb761对脑缺血再灌注后大鼠中脑胶质细胞和多巴胺神经元的影响

《egb761对脑缺血再灌注后大鼠中脑胶质细胞和多巴胺神经元的影响》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、AbstractEffectsofEGb761onglialcellanddopaminergicneuronolmesenceohallCincereDraliscllemlainratsn■_●●_■-■●PostgraduateZhoufangDuanSupervisorProf．JinlanWangDepartmentofNeurologyTheSecondClinicalCollegeofZhengzhouUniversityZhengzhou，Henan450014，ChinaBackgroundandobjectiveIschemiccer

2、ebralvasculardisease(ICVD)seriouslyendangerhuman’shealth，itisoneofthemostcommonillnesseswithfeaturesofhighmobilityanddisabilityrate．Atpresent，theresearchonischemiccerebralvasculardiseasewerefocusedmainlyinlocal，butthedamageabouttheremotebraintissueandcellswithischemicinfarctionar

3、eless．Inrecentyears，someresearchershaveshownthatcerebralinfarctionWasnotonlyafocaldamage，butalsocausedsecondarydamageinareasremotefromtheischemicterritory,whichwillretardtherecoveryofneurologicalfunction．Glialfibrillaryacidicprotein(GFAP)iSoneofthemainintermediatefilamentproteins

4、inastrocytes，asamarkerofmatureastrocytesactivationproteinwhoseincreasingexpressionCanpartlyreflectthedamageofbraintissue．Tyrosinehydroxylase(TH)distributemainlywithinmesencephalicsubstantianigracompacta,whichwasusuallyregardedasamarkerofdopaminergicneuronsinthebrain．ThedeclineofT

5、H’SactivitynotonlyCandecreasetheformationofDAwhichpromotetheDAneuronscelldegenerationandnecrosis，butalsoCanincreasethesensitivityofthecellsofexogenouspoisons．IVAbstractTheGinkgobilobaextract(EGb761)，astandardizedextract，isacomplexmixtureofingredientsincluding24％flavonoidand6％terp

6、enoid，etc．NowadayssomanystudiesabouttheeffectofEGb761werefocusontheinjuredneuroglialcellsincerebralischemiainjury,butfewofthemconcentrateonglialcellsagainstischemiadamage．furthermoreitsprotectiveeffectoilremotesitesofinjuryanditsmechanismwerenotclear．Consequently,weestablishedthe

7、rats’modelswithcerebralischemia-reperfusioninjuryandobservedeffectofEGb761ontheexpressionsofGFAP，THandtheapoptosischange，toprovidethetheoreticalbasisforclinicaltreatment．MaterialsandMethods1Experimentalanimalsandgrouping：54cleangradehealthymaleSpragueDawleyrats，weighting220a：309，

8、fromtheExperimentalAnimalCenterofZhengzh