血塞通联合低分子肝素钠治疗不稳定性心绞痛的临床观察

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1、血塞通联合低分子肝素钠治疗不稳定性心绞痛的临床观察(荷泽鲁心心脑血管病医院山东荷泽274000)【摘要】目的：观察血塞通与低分子肝素钠联合治疗不稳定性心绞痛的临床疗效及对血液流变学、血脂的影响。方法：将所观察的124例患者随机分为治疗组(注射用血塞通与低分子肝素钠组)64例，对照组(阿司匹林与低分子肝素钠组)60例，分别治疗7d后观察临床疗效,14d后观察血液流变学及血脂的变化。结果：治疗组总有效率及治疗后心绞痛发作次数、心绞痛持续时间、发作间隔时间、Holter24h缺血总时间等改善方面均优于对照

2、组(P<0.05)。两组治疗后全血黏度(高切、低切)、血浆黏度、甘油三酯、胆固醇均较治疗前明显下降(P<0.05,P<0.01),其中全血高切比黏度的降低治疗组优于对照组(P<0.05),而且治疗组能明显降低患者的纤维蛋白原(P<0.01)。结论：注射用血塞通与低分子肝素钠联合治疗不稳定性心绞痛疗效显著，且能降低血脂、血黏度及纤维蛋白原而无出血现象发牛，而且没有增加出血等并发症。【关键词】注射用血塞通；低分子肝素钠；不稳定性心绞痛；临床疗效【中图分类号】R541【文献标

3、识码】A【文章编号】1004-6194(2015)02-0116-02Clinicalobservationofpanaxnotoginsengsaponinscombinedwithlowmolecularweightheparin・Natherapyforunstableangina[Abstract】Objectives:Toobserveclinicalcurativeeffectofpanaxnotoginsengsaponinscombinedwithlowmolecularweight

4、heparin・Natherapyforunstableangina,andtheeffectsonbloodrheologyandbloodlipid.Methods:124patientswithunstableanginawererandomlydividedintotreatmentgroupandcontrolgroup,thetreatmentgroup(64patientsjtreatedbypanaxnotoginsengsaponinsforinjectioncombinedwit

5、hlowmolecularweighthepariNa,thecontrolgroup(60patients)treatedbyaspirincombinedwithlowmolecularweighthepariNa.CIinicalcurativeeffectwereobservedrespectivelyafter7daystreatment,andtheeffectsonbloodrheologyandbloodlipidwereobservedafter14daystreatment・Re

6、sults:Treatmentgroupwasbetterthancontrolgroupontotaleffectiverate,attackfrequencyofanginapectoris,durationofanginapectoris,onsettimeinterval,total24hHolterischemiatime(P<0.05).Significantlowerofwholebloodviscosity(highshearjowshear),plasmaviscosity,

7、triglycerideandcholesterolwerefoundinthetwogroups(P<0.05,P<0.01)Jnwhichthewholebloodhighshearviscositywaslowerthancontrolgroup(P<0.05).Theleveloffibrinogenintreatmentgroupwaslowerthancontrolgroupaftertreatment(P<0.01).Conelusions:Panaxnotog

8、insengsaponinsforinjectioncombinedwithlowmolecularweightheparin・Nahavegoodeffectontherapyforunstableangina,andcoulddecreasebloodlipids,bloodviscosityandfibrinogenwithoutcomplicationssuchasbleeding.【Keywords]panaxnotoginsengsaponinsforin