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1、提要目的:观察健脾除湿,泄浊通络法治疗原发痛风性关节炎慢性期的临床疗效,并探讨其病因病机。方法:采用随机、阳性药物对照方法,选取60例痛风性关节炎慢性期痰浊阻滞证患者,分为试验组30例,予健脾泄浊方加别嘌醇治疗;对照组30例,予别嘌醇治疗,分别观察6周。采用降尿酸疗效判定及中医证候疗效判定标准,评价健脾除湿,泄浊通络法对痛风性关节炎慢性期的治疗效果。结果:1.两组治疗前后自身比较,均能明显降低血尿酸水平,差异有统计学意义(P<0.05)。两组间比较,第2、4周差异无统计学意义(P>0.05);第6
2、周差异有统计学意义(P<0.05),试验组疗效优于对照组。2.在中医症状积分方面,治疗后两组对症状积分均有改善,差异有统计学意义(P<0.05);组间比较,差异有统计学意义(P<0.05),第4、6周试验组疗效均优于对照组。在改善单项症状方面,治疗后两组均有效,经统计学分析差异有统计学意义(P<0.05);两组间比较,治疗后4周试验组在改善关节疼痛、关节肿胀、神疲乏力方面优于对照组,差异有统计学意义(P<0.05);治疗后6周在改善关节疼痛、关节肿胀、神疲乏力、关节活动不利、舌象方面优于对照组,差
3、异统计学意义(P<0.05)。结论:健脾泄浊方联用别嘌醇治疗痛风性关节炎慢性期,在降低血尿酸水平,改善关节疼痛、关节肿胀、关节活动不利、神疲乏力、舌象以及中医症状积分方面疗效优于单用别嘌醇。关键词痛风性关节炎;慢性期;健脾泄浊;别嘌醇TheClinicalresearchontheTraditionalChineseMedicinePrescriptionJianpiXiezhuointreatmentofchronicgoutSpeciality:InternalMedicineofT.C.M,
4、RheumaticDiseaseAuther:ChenJianTuter:ProfessorSunSuPingAbstractObjective:ThepurposeofthisarticleistoObservationofstrengtheningspleenandeliminatingdampness,XiezhuoTongluotherapyinthetreatmentofprimarychronicgoutyarthritisclinicalefficacy,anddiscussitse
5、tiologyandpathogenesis.Methods:Usingarandomized,positivedrugcontrolmethod,weselected60casesofgoutyarthritischronicphlegmsyndrome,dividedintotheexperimentalgroup30cases,JianpiXiezhuoRecipetoaddallopurinoltreatment;30casesinthecontrolgroup,toallopurinol
6、treatment,wereobservedfor6weeks.TheuricaciddeterminationofcurativeeffectandsyndromeoftraditionalChinesemedicinecurativeeffectevaluationcriterion,strengtheningspleenandeliminatingdampnessanddredgingcollateralsmethod,turbidityongoutyarthritischronicphas
7、etreatment.Results:1.ofthetwogroupsbeforeandaftertreatmentoftheircomparative,cansignificantlylowerblooduricacidlevel,thedifferencewasstatisticallysignificant(P<0.05).Comparisonbetweentwogroups,second,4weekshadnosignificantdifference(P>0.05);sixthweeks
8、therewerestatisticallysignificantdifferences(P<0.05),thetestgroupwasmoreeffectivethanthecontrolgroup.2.inTCMsymptomscore,intwogroupsafterthetreatmentofsymptomscoreshaveimproved,thedifferencewasstatisticallysignificant(P<0.05);comparisonbetween