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ID:32860144
大小:2.31 MB
页数:32页
时间:2019-02-16
《偏头痛患者中脑深部核团磁共振功能成像—扩散张量成像研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、重庆医科大学硕士学位论文偏头痛患者中脑深部核团磁共振功能成像--扩散张量成像研究姓名:王静杰申请学位级别:硕士专业:影像医学与核医学指导教师:李咏梅201204重庆医科大学硕士研宄生学位论文偏头痛患者中脑深部核团磁共振功能成像一扩散张量成像研究摘要目的:用3.OT磁共振扩散张量成像(MR.DTI)定量分析偏头痛患者中脑导水管周围灰质(PAG)、黑质(sN)、红核(IⅢ)的微观结构改变,并探讨这些结构的DTI数据改变与偏头痛发病相关性。方法:选取符合临床诊断标准偏头痛患者42例、性别年龄匹配的健康志愿者22例行T2WI、3D.TOF.MRA和DTI扫描,获得到一系列MR数据,
2、选择双侧导水管周围灰质、黑质、红核为感兴趣区(ROIs),ROIs内T2WI显示可视病灶或颅内有脑血管病变的研究对象被排除,测量每个符合要求的研究对象ROIs的MD值、FA值,采用独立样本/检验分别比较偏头痛组与对照组及偏头痛亚组间两组数据的差异,并采用Spearman秩相关分析评估各指标与偏头痛是否具有相关性,以尸3、尸>0.05)无统计学意义外,其余各区域改变均具有统计学意义(尸4、G是偏头痛发病的特异性结构。关键词:扩散张量成像;偏头痛;中脑导水管周围灰质;黑质;红核重庆医科大学硕士研究生学位论文ADIFFUSIoNTENSoRⅣIAGNETICRESONANCEIⅣIAGINGSTUDYoFDEEPMⅡIBRADiNUCLEIOFPATIENTSWITHMIGRAmEObjective:Tomeasurepathologicaldamageofperiaqueductalgray(PAG)、rednucleus(RN)、substantianiagra(SN)ofpatientswithmigraine.,usingdiffusiontensorm5、agneticresonanceimaging(DT-MRI)quantitatively,anddiscussthecorrelationoftheDTIchangeswithmigrainepathogenesis.Methotis:DT-MRl、T2WIand3D—TOF.MRAscansofthebrainwereacquiredfrom42patientswithmigraineand22sex·-andage--matchedhealthyvolunteers.Meandiffilsivity(MD)andfractionalanisotropy(FA)ofth6、ePAG、RN、SNwereobtainedfromallsubjects.TheparticipantswouldbeexcludedWhenthelesionswerevisibleintheROIsonT2imagesorcerebralvascularabnormalitieswerepresented:BothFAandMDvalueswerecomparedbetweengroupsandsubgroupsusingstudentltes/andSpearmancorrelationwasanalyzed.尸<0.05wasdeclaredstatistical7、lysignificantResults:(1)Incomparisonwithhealthyvolunteers,FAvaluesofpatients重庆医科大学硕士研究生学位论文withmigrainewerelower(尸<0.05)andMDhigher(尸<0.05)inbilateralPAGregions.(2)Therewerestatisticallydifferences(尸
3、尸>0.05)无统计学意义外,其余各区域改变均具有统计学意义(尸4、G是偏头痛发病的特异性结构。关键词:扩散张量成像;偏头痛;中脑导水管周围灰质;黑质;红核重庆医科大学硕士研究生学位论文ADIFFUSIoNTENSoRⅣIAGNETICRESONANCEIⅣIAGINGSTUDYoFDEEPMⅡIBRADiNUCLEIOFPATIENTSWITHMIGRAmEObjective:Tomeasurepathologicaldamageofperiaqueductalgray(PAG)、rednucleus(RN)、substantianiagra(SN)ofpatientswithmigraine.,usingdiffusiontensorm5、agneticresonanceimaging(DT-MRI)quantitatively,anddiscussthecorrelationoftheDTIchangeswithmigrainepathogenesis.Methotis:DT-MRl、T2WIand3D—TOF.MRAscansofthebrainwereacquiredfrom42patientswithmigraineand22sex·-andage--matchedhealthyvolunteers.Meandiffilsivity(MD)andfractionalanisotropy(FA)ofth6、ePAG、RN、SNwereobtainedfromallsubjects.TheparticipantswouldbeexcludedWhenthelesionswerevisibleintheROIsonT2imagesorcerebralvascularabnormalitieswerepresented:BothFAandMDvalueswerecomparedbetweengroupsandsubgroupsusingstudentltes/andSpearmancorrelationwasanalyzed.尸<0.05wasdeclaredstatistical7、lysignificantResults:(1)Incomparisonwithhealthyvolunteers,FAvaluesofpatients重庆医科大学硕士研究生学位论文withmigrainewerelower(尸<0.05)andMDhigher(尸<0.05)inbilateralPAGregions.(2)Therewerestatisticallydifferences(尸
4、G是偏头痛发病的特异性结构。关键词:扩散张量成像;偏头痛;中脑导水管周围灰质;黑质;红核重庆医科大学硕士研究生学位论文ADIFFUSIoNTENSoRⅣIAGNETICRESONANCEIⅣIAGINGSTUDYoFDEEPMⅡIBRADiNUCLEIOFPATIENTSWITHMIGRAmEObjective:Tomeasurepathologicaldamageofperiaqueductalgray(PAG)、rednucleus(RN)、substantianiagra(SN)ofpatientswithmigraine.,usingdiffusiontensorm
5、agneticresonanceimaging(DT-MRI)quantitatively,anddiscussthecorrelationoftheDTIchangeswithmigrainepathogenesis.Methotis:DT-MRl、T2WIand3D—TOF.MRAscansofthebrainwereacquiredfrom42patientswithmigraineand22sex·-andage--matchedhealthyvolunteers.Meandiffilsivity(MD)andfractionalanisotropy(FA)ofth
6、ePAG、RN、SNwereobtainedfromallsubjects.TheparticipantswouldbeexcludedWhenthelesionswerevisibleintheROIsonT2imagesorcerebralvascularabnormalitieswerepresented:BothFAandMDvalueswerecomparedbetweengroupsandsubgroupsusingstudentltes/andSpearmancorrelationwasanalyzed.尸<0.05wasdeclaredstatistical
7、lysignificantResults:(1)Incomparisonwithhealthyvolunteers,FAvaluesofpatients重庆医科大学硕士研究生学位论文withmigrainewerelower(尸<0.05)andMDhigher(尸<0.05)inbilateralPAGregions.(2)Therewerestatisticallydifferences(尸
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