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ID:32848703
大小:3.01 MB
页数:46页
时间:2019-02-16
《肺血栓栓塞患者再栓塞相关因素研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、河北医科大学硕士学位论文肺血栓栓塞患者再栓塞相关因素研究姓名:宫小薇申请学位级别:硕士专业:内科学指导教师:袁雅冬201203中文摘要肺血栓栓塞患者再栓塞相关因素研究摘要目的:再栓塞是肺血栓栓塞患者主要不良预后事件之一,关于再栓塞率及相关危险因素目前尚无统一结论,本研究通过长期追踪观察临床确诊的肺栓塞患者,旨在了解再栓塞发生隋况及相关危险因素。方法:收集1998年1月至2011年6月在河北医科大学第二医院住院期间经螺旋CT肺血管成像(CTPA)或肺通气灌注扫描确诊的肺血栓栓塞患者的病例资料,并进行平均28个月(确诊之日至161个月)的随访调查,分析再栓塞发生情
2、况。应用单因素分析(t检验或f检验)时选择P<0.10的变量进入回归模型进一步分析,对可能有意义的因素行多因素非条件logistic回归分析,寻找再栓塞危险因素。结果:在161个月内接受随访的385例肺栓塞患者中48例发生再栓塞,再栓塞发生的时间构成比依次为:第1年50.O%(24例),第2年22.92%(11例),第3年lO.42%(5例),第4年5.41%(2例),第5年5.4l%(2例),第6年5.41%(2例),第7年2.70%(1例),第8年2.70%(1例)。单因素分析(P3、抗凝治疗(<3月)、年龄>65岁、吸烟、高血压、下肢深静脉血栓、低氧血症等与再栓塞具有相关性(P65岁(OR-9.518)、吸烟(OR=5.464)是发生再栓塞的独立危险因素(P4、,以后随着时间的推移再栓塞发生率逐年下降,并且在所有肺栓塞的危险因素中,D.dimer持续阳性、右心功能不全、特发性PTE、短疗程抗凝治疗(<3月)、年龄>65岁、吸烟是发生再栓塞的独立危险因素。关键词:肺栓塞肺血栓栓塞再栓塞危险因素英文摘要TheResearchofRelatedFactorsaboutPatientswithPulmonaryEmbolismRecrurrenceABSTRACTObjective:Recurrenceisoneofthemainadverseprognosticeventsamongpatientswithpulmonar5、yembolism.Thereisnoconsistentconclusionsontherateofrecurrenceandrelatedriskfactors.Inthisstudy,patientswithdiagnosisofpulmonaryembolismwereobservedbylong-termfollow-up,aimedatdiscoveringtherecurrenceandrelatedriskfactors.Methods:CasesofpatientsdiagnosedbySpiralCTpulmonaryangiography6、(CTPA)orlungventilation/perfusionscaninTheSecondHospitalofHebeiMedicalUniversityfromJanuary1998toJune201wereanalyzedretrospectively加allaverageof28months(thedateofdiagnosistothe161stmonth)follow-up.Univariateanalysis(ttestorftes0selectedP7、analysisandmultivariateunconditionallogisticregressionanalysisofthelinesthatmaybesignificantfactorsinprogress,lookingfortherelatedriskfactorsofrecurrence.Results:Duringthe161monthsfollow-up,48in385casesofpulmonaryembolismrecurrent.Theconstituentratioasfollows:1-year50.O%(24cases),2-8、year22.92%(11cases)
3、抗凝治疗(<3月)、年龄>65岁、吸烟、高血压、下肢深静脉血栓、低氧血症等与再栓塞具有相关性(P65岁(OR-9.518)、吸烟(OR=5.464)是发生再栓塞的独立危险因素(P4、,以后随着时间的推移再栓塞发生率逐年下降,并且在所有肺栓塞的危险因素中,D.dimer持续阳性、右心功能不全、特发性PTE、短疗程抗凝治疗(<3月)、年龄>65岁、吸烟是发生再栓塞的独立危险因素。关键词:肺栓塞肺血栓栓塞再栓塞危险因素英文摘要TheResearchofRelatedFactorsaboutPatientswithPulmonaryEmbolismRecrurrenceABSTRACTObjective:Recurrenceisoneofthemainadverseprognosticeventsamongpatientswithpulmonar5、yembolism.Thereisnoconsistentconclusionsontherateofrecurrenceandrelatedriskfactors.Inthisstudy,patientswithdiagnosisofpulmonaryembolismwereobservedbylong-termfollow-up,aimedatdiscoveringtherecurrenceandrelatedriskfactors.Methods:CasesofpatientsdiagnosedbySpiralCTpulmonaryangiography6、(CTPA)orlungventilation/perfusionscaninTheSecondHospitalofHebeiMedicalUniversityfromJanuary1998toJune201wereanalyzedretrospectively加allaverageof28months(thedateofdiagnosistothe161stmonth)follow-up.Univariateanalysis(ttestorftes0selectedP7、analysisandmultivariateunconditionallogisticregressionanalysisofthelinesthatmaybesignificantfactorsinprogress,lookingfortherelatedriskfactorsofrecurrence.Results:Duringthe161monthsfollow-up,48in385casesofpulmonaryembolismrecurrent.Theconstituentratioasfollows:1-year50.O%(24cases),2-8、year22.92%(11cases)
4、,以后随着时间的推移再栓塞发生率逐年下降,并且在所有肺栓塞的危险因素中,D.dimer持续阳性、右心功能不全、特发性PTE、短疗程抗凝治疗(<3月)、年龄>65岁、吸烟是发生再栓塞的独立危险因素。关键词:肺栓塞肺血栓栓塞再栓塞危险因素英文摘要TheResearchofRelatedFactorsaboutPatientswithPulmonaryEmbolismRecrurrenceABSTRACTObjective:Recurrenceisoneofthemainadverseprognosticeventsamongpatientswithpulmonar
5、yembolism.Thereisnoconsistentconclusionsontherateofrecurrenceandrelatedriskfactors.Inthisstudy,patientswithdiagnosisofpulmonaryembolismwereobservedbylong-termfollow-up,aimedatdiscoveringtherecurrenceandrelatedriskfactors.Methods:CasesofpatientsdiagnosedbySpiralCTpulmonaryangiography
6、(CTPA)orlungventilation/perfusionscaninTheSecondHospitalofHebeiMedicalUniversityfromJanuary1998toJune201wereanalyzedretrospectively加allaverageof28months(thedateofdiagnosistothe161stmonth)follow-up.Univariateanalysis(ttestorftes0selectedP7、analysisandmultivariateunconditionallogisticregressionanalysisofthelinesthatmaybesignificantfactorsinprogress,lookingfortherelatedriskfactorsofrecurrence.Results:Duringthe161monthsfollow-up,48in385casesofpulmonaryembolismrecurrent.Theconstituentratioasfollows:1-year50.O%(24cases),2-8、year22.92%(11cases)
7、analysisandmultivariateunconditionallogisticregressionanalysisofthelinesthatmaybesignificantfactorsinprogress,lookingfortherelatedriskfactorsofrecurrence.Results:Duringthe161monthsfollow-up,48in385casesofpulmonaryembolismrecurrent.Theconstituentratioasfollows:1-year50.O%(24cases),2-
8、year22.92%(11cases)
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