基于蜂毒肽类风湿关节炎基因治疗的研究

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1、基于蜂毒肽的类风湿关节炎基因治疗研究研究生：李晶华学科专业：中西医结合临床所在单位：第四军医大学第一附属医院中医科导师：王宗仁教授（主任医师）辅导教师：李军昌副教授资助基金项目：国家自然基金项目30800919；30972517关键词：类风湿关节炎；蜂毒；蜂毒肽；基因治疗中国人民解放军第四军医大学2010年5月第四军医大学博士学位论文目录缩略语表············································································································1中文摘要···

2、·········································································································2英文摘要············································································································8前言·····································································

3、·····································14文献回顾··········································································································16第一部分：类风湿关节炎的基因治疗研究进展········································16第二部分：细胞因子在类风湿关节炎中的作用········································25正文·············

4、·····························································································44第一部分：蜂毒肽抗风湿作用研究···························································44材料···································································································44方法··············

5、·····················································································46结果···································································································50讨论··································································································

6、·57小结···································································································60参考文献···································································································60第二部分：蜂毒肽重组腺相关病毒及其体外鉴定····································62材料··················

7、·················································································63方法···································································································64结果········································································