应用高通量测序分析母婴皮肤细菌群落多样性

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1、万方数据应用高通量测序分析母婴皮肤细菌群落多样性_—————————————————————————————————————————————一ExplorationofSkinBacterialCommunitybetweenMotherandInfantthroughHigh-ThroughputPyrosequencingSkinmicrobesplayimportantroles：theycoverthehumanskinandliveonthenutritionproducedbyhuman

2、beings，andconverselytheywillactonskinmetabolism；meanwhile，environmentwillalsoaffecttheseorganisms．Differentiatedskincharacterdeterminedthemicrobialcommunityinparticularsites．Previously，abasisunderstandingofskinmicrobeshasformedusingculture-dependentmet

3、hod·Deficientofwatercontent，skinmicrobesaredominatedbygram‘positivebacteria，whilegram．negativebacteriaaremoreabundantinmoistsites．Recently，manyresearchersbegantostudyskinmicroflorausing16SrRNAgenemarker．Ratherthanidentifyingsomespecialkindofbacteria，th

4、esestudiesfocusedontheinteractionofskinnichesandmicrobialcommunity．Comparedtoothernichessuchassoilormadne．1essdiversespeciesarepresentinskin．Thesespeciesembracerelativehighabundanceandexiststeadily，whichimpliedthattheymaybecrucialtoskinhealth．Thisstudy

5、analyzedmotherandinfantskinmicrobialinordertosolveseveralquestions：11Differencesamonghumansebaceous，moistanddrysites；2)Coremicrobesinmotherandinfants；31Relationbetweeninfantmicrobesandouterenvironment；41Correlationofmicrobialcommunitiesbetweenmotherand

6、infant．Conclusionwillbedrawncombinedwithpreviousstudies．Inthisstudy，skinbacteriaaremainlyfromActinobacteria，Firmicutes，ProteDb口cteriaandBacteroidetes．Thecorememberofmotherandinfantisthesimilar．However，theabundancevaries．Therearealsosomedifferencesinoth

7、ercommonresidents．ThepercentageofPropionibacteriumishigherinmothers’skinsitesthaninfants’；itsgrowthishighrelatedtosebum．StreptococcusandStaphylococcusaretwomainorganismsininfantskin；moreover，Staph)7lococcusismoreabundantincaesareanbirththanvaginalbirth

8、．Bacterialmembersoftheinfantareclosertohismother，whilebacterialstructureismoresimilartootherinfants．Mostoftheuniquegeneradetectedininfantarethecommonoralbacteria，whichdisplaysthepossibilitythatthefirstcolonizationofhumanskinmicrobesmayf