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ID:32702449
大小:11.67 MB
页数:78页
时间:2019-02-14
《应用高通量测序分析母婴皮肤细菌群落多样性》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、万方数据应用高通量测序分析母婴皮肤细菌群落多样性_—————————————————————————————————————————————一ExplorationofSkinBacterialCommunitybetweenMotherandInfantthroughHigh-ThroughputPyrosequencingSkinmicrobesplayimportantroles:theycoverthehumanskinandliveonthenutritionproducedbyhuman
2、beings,andconverselytheywillactonskinmetabolism;meanwhile,environmentwillalsoaffecttheseorganisms.Differentiatedskincharacterdeterminedthemicrobialcommunityinparticularsites.Previously,abasisunderstandingofskinmicrobeshasformedusingculture-dependentmet
3、hod·Deficientofwatercontent,skinmicrobesaredominatedbygram‘positivebacteria,whilegram.negativebacteriaaremoreabundantinmoistsites.Recently,manyresearchersbegantostudyskinmicroflorausing16SrRNAgenemarker.Ratherthanidentifyingsomespecialkindofbacteria,th
4、esestudiesfocusedontheinteractionofskinnichesandmicrobialcommunity.Comparedtoothernichessuchassoilormadne.1essdiversespeciesarepresentinskin.Thesespeciesembracerelativehighabundanceandexiststeadily,whichimpliedthattheymaybecrucialtoskinhealth.Thisstudy
5、analyzedmotherandinfantskinmicrobialinordertosolveseveralquestions:11Differencesamonghumansebaceous,moistanddrysites;2)Coremicrobesinmotherandinfants;31Relationbetweeninfantmicrobesandouterenvironment;41Correlationofmicrobialcommunitiesbetweenmotherand
6、infant.Conclusionwillbedrawncombinedwithpreviousstudies.Inthisstudy,skinbacteriaaremainlyfromActinobacteria,Firmicutes,ProteDb口cteriaandBacteroidetes.Thecorememberofmotherandinfantisthesimilar.However,theabundancevaries.Therearealsosomedifferencesinoth
7、ercommonresidents.ThepercentageofPropionibacteriumishigherinmothers’skinsitesthaninfants’;itsgrowthishighrelatedtosebum.StreptococcusandStaphylococcusaretwomainorganismsininfantskin;moreover,Staph)7lococcusismoreabundantincaesareanbirththanvaginalbirth
8、.Bacterialmembersoftheinfantareclosertohismother,whilebacterialstructureismoresimilartootherinfants.Mostoftheuniquegeneradetectedininfantarethecommonoralbacteria,whichdisplaysthepossibilitythatthefirstcolonizationofhumanskinmicrobesmayf
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