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《广东顺德人群dna修复基因xpc第8、15外显子多态性与环境因素交互作用对原发性肝癌的影响研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、carriedouttheformalinvestigationduring2007.1～2007.12,andtheperipheryvenousbloodofthecasesandcontrolshadbeencollected.Byapplyingmolecularbiologytechnology,wehavedetectednucleotideexcisionrepairgeneXPC8,15exonsgenotypes,entereddatawithEpiData3.1,andanalyzedthemwithSPSS13.0,utilizedcondi
2、tionallogisticregressionandcaseonlystudytoanalyzetherelationshipamongenvironmentalfactors,geneandthedevelopmentofPHC,andprobedtheinteractionofgene-environmentandgene-geneaswell.Results1environmentalriskfactorsofprimaryhepaticcarcinomaThevariablesultimatelyhaveenteredtheconditionalmult
3、iplefactorslogisticregressionanalysisareHBsAgconditionandtotalquantityofdrinkingwine,theirORis6.113（95%CI:1.948～19.180）,3.557（95%CI:0.932～13.572）.2theeffectofHBVinfectionandotherenvironmentalriskfactorsinteractiononlivercancerTheinteractionORofHBVinfectionandeatinglivefishes,gruelwith
4、livemeatorfish,drinkingwellwateris8.397（95%CI:2.122～33.236）,6.156（95%CI:1.872～20.241）,5.677（95%CI:1.415～22.782）;thesynergisticalORofHBVandHCVinfectionis11.742（95%CI:1.412～97.618）.3theeffectofXPCgeneAla499Val、Lys939GInpolymorphismsandenvironmentalinteractiononlivercancerTheORofnon-alco
5、holuserwhocarriesatleastamutantgeneofAla499Valis1.567（95％CI:0.449～5.470）,andonlydrinkingwineonesassociationwithlivercanceris4.268（95％：1.169～15.584）,buttheORofthosealcoholuserwhocarryatleastamutantgeneofAla499Valis1.785（95％:0.573～5.563）.OnlywithHCVinfection,onesORis8.799(95％CI:1.076～71
6、.940),andnotonlyHCVinfectionbutalsocarryatleastamutantgeneofLys939GIn,onesORis1.56(95%CI:0.425～5.728).4explorationofcaseonlycontrolTheconsequenceofgene-environmentofcaseonlycontrolisclosetocase-controlVstudy,anditcouldreplacethelatterwhenthebloodofcontrolisdifficulttobecollected.Concl
7、usions1HBVinfection,drinkingwinearethemajorriskfactorsofprimaryhepaticcarcinomainGuangdongShunde.2CarryC/TorT/TgenotypesofXPCgenes8exonAla499Valcouldlowertheriskofpeoplewhodrinkwinetogetlivercancer;andwith15exonLys939GInA/CorC/CgenotypescouldalsodecreasetheoneswithHCVinfectiontosuffer
8、liver
