唾液中一氧化氮含量与牙周炎的相关性研究

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1、CorrelationbetweennitricoxidelevelinsalivaandperiodontitisAbstractObjective：InordertostudythepossibleroleofNOinthedevelopmentofperiodontitis，wemeasuredtheconcentrationofNOinthesalivaofpatientwithperiodontitisandhealthysubjects．ThecorrelationbetweenNOlevelsinsalivaofpatientswi

2、thperiodontaldiseaseandclinicalperiodontaldiseaseindexwasinvestigated．Furthermore，weexpecttoknowwhetheritiscausativeinthepathogenesisofthedisease．Methods：Inthisstudy52patientssufferingchronicperiodontitiswereselectedastestgroupand25periodontallyhealthypersonswereselectedascon

3、trolgroup．Totally120periodontalpocketswerestudiedintestgroup．SalivaWascollectedafteroralcavityirrigationwithwater．AllpatientsweretreatedwithfullmouthSRP．Thechangesofperiodontalclinicalindices(attachmentlossAL，probingdepthPD，sulcusbleedingindexSBI)andtheconcentrationofNOinthes

4、alivaweremonitored．TheindexessuchasAL，PDandSBlwereobservedatthebaselinelevelandonthe7th。14tlI，21thand30mdayaftertreatment．respectively．WehaveanalyzedsalivaryNOconcentrationsin52subjectswithchronicperiodontitisandin25periodontally—healthypersons．TheconcentrationsofNOweredeterm

5、inedbythemethodofGriessreaction．Results：TheresultsshowedthattheaveragelevelofNOinsalivawere73．13+2．37umol／Lincontrolgroup．Therewasnodifferencebetweenmaleandfemale(P>0．05)．Intestgroup，theconcentrationofNOwassignificantlylowerat7th，14也，21ththanthatat1tII，7伯，14m，respectively(P<0

6、．05)，whiletherewerenosignificantdifferencebetweenat30thandat21th(P>0．05)．TheconcentrationofNOweresignificantdifferencecomparedtestgroupandcontrolgroupatbaseline，7th'14m(尸<0．05)，whiletherewerenosignificantdifferencecompared30mand21thinbothgroup(P>0．05)．Alltheperiodontalindices

7、oftestgroupswereimprovedobviouslyafterbasictreatments．Theirdifferenceswerestatisticallysignificant(P<0．05)．PD、AL、SBlwereimprovedobviouslyintestgroupat7th'14如thanthatat1曲，7mrespectively(P<0．05)。PD、SBlwereimprovedobviouslyintestgroupat21山thanthatat14山respectivelyfP<0．05)．Allthe

8、clinicalperiodontalindiceswerenosignificantdifferercecompared30“1、vi