hpv感染、fhit基因缺失与非吸烟女性肺癌的相关性研究

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1、肺癌的危险因素；2、肺癌组织中FHIT基因转录本缺失频率高于对照组织，HPV16感染增加了肺癌组织中该基因转录本的缺失频率；3、HPV16感染与FI,-IIT基因缺失对非吸烟女性肺癌的影响存在正相加模型交互作用。关键词HPV感染；FHIT；肺癌；非吸烟女性·英文论著摘要·RelationshipamongHPVinfection，FHITdeletionand’lungCancerinnon-smokmgtemaleo●'‘n’IntroductionLungcancerisaseriousproble

2、minpublichealth；themorbidityandthemortalityhavebeenincreasingrapidly．Itisshownthatmostofthegasesarcnon—smokingwomen,andtheriskfactorsarestillunclear．Anassociationofhumanpapillomavirus(HPV)infectionwithlungcancoramongnon-smokingwomenwasrevealedinpreviouss

3、tudy．Thefragilehistidinetriad(FⅢDgenehadbeenreportedafrequentdeletioninsmokinglungcancerandHPV-associatedcervicalcancer．Inourstudy，weinvestigateaberranttranscriptsofFHITgencinnon—smokingfemalelungcancer，explorei：tsrelationwithHPVinfectionandassessthegene

4、-environmentalinteraction．MaterialsandMethodsTherewere60patientswithhistologicallyconfirmedincidentlungcancerrecruitedbeforeanyradiotherapyOrchemotherapy。Controlwomenwithoutapreviousdiagnosisofcancerwererecruitedfromthesamehospital，withageasmatchingcrite

5、ria．AlloflungcancerspecimensandbenignlesionspecimenswereexaminedforthefragmentofHPV-DNAbyPeR,usingRT-PCRtodetectaberranttranscriptsofFHIT．Questionnaire，includingthecharacterofdemography，thehistoryofpassivesmoking，theexposedhistoryofcookingfume，thefuelexp

6、osure，theexposedhistoryofcoalfume，thehistoryofpreviousdiseasesoflung，theCanCel"historyofrelativesandtheoccupationalhistory，Wasusedtodetectriskfactorsofnon-smokingfemalelungcancer．AllofthestatisticalanalyseswereperformedbytheSPSSstatisticalsoRware(version

7、13．o)．Pearson’S，testandFisherexactprobabilitytestwereusedtotestthedifferencesbetweentheeaseandcontr01．ORsand95％Clswerecalculatedasallestimateoftherelativerisk．Usecrossoveranalysistoassessthegene-environmental4interaction．RERj．s，APwerecalculatedfortheinte

8、raction．ResultsnleprevalenceforHPVL1、HPV16andHPVl8is31．67％(19160)，20．00％(12／60)and18。33％(11／60)，respectively．HPV16hadahigherprevalenceincancertissuethanthatinbenignlesiontissuesp=0．032)，ORis3．500．FHITaberrant缸anscfipmismor