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1、中风皂贝化痰胶囊对大鼠脑缺血再灌注损伤血管内皮生长因子表达的影响InfluenceofZhongfengZaobeiHuatanJiaonangontheExpressionofVascularEndothelialGrowthFactorinRatswithFocalCerebralIschemia-ReperfusionInjuryHanyanli(InteralMedicineofTraditionalChineseMedicine)DirectedbyprofessorWangbaoliangAbstractObjective:Thechange
2、softheScoreinneurological,pathdeficits,measurementofinfarctvolume,pathologicalinbrain,vascularendothelialgrowthfactor(VEGF)wereobservedwithdiscussedtheprotectiveeffectinratswithfocalcerebralischemicreperfusion.Method:70SDratswererandomlydividedintonormal(n=10),model(n=10),high-do
3、se(n=10),medium-dose(n=10)andlow-dosegroup(n=10).Establishedthemiddlecerebralarteryocclusionmodelwithsuturemethodbyreperfusion24hafterischemic2haccordingtoZea-Longa.Theneurologicaldefectivescores，PathologicalinBrainandtheVEGFwereevaluatedafteroperation.Results：1.TheScoreofNeurolo
4、gicalDeficitThenormalgrouphavenoneurologicaldeficit；comparethemodel,high-dose,medium-dose,low-dosegroupandnormalgroup,thescoreswereremarkedlow(p<0.05).2.MeasurementofInfarctVolumeThefocalinfarctofthenormalgroupwasnotseen;comparethehigh-dose,medium-dose,low-dosegroupandthemodelgro
5、up,thetheformerInfarctVolumewasdecrescent(p<0.05).3.ExpressionofVEGFAfterischemia-reperfusion,theexpressionofVEGFinmodelgroupsandhigh,medium,andlow-dosegroupwereenhanced(p<0.05),normalgroupwasnotexpressed;theeffectsofhigh-doseandmedium-doseweremoreenhancedthanmodelgroup,andthehig
6、h-dosegroupwasenhancedsignificantly(p<0.05).4.PathologicalchangesinbraintissueThemorphologyofthebrainandnervecellwasnormalinmodelgroup;inmodelgroup,theswollenkaryonandglialcells,disorganized,infarct,reductionofnumbers,highedema,vaguestructural,inflammatorycellswerevisibled.AndItw
7、asvisibledthatthedisorganizedofneuronsandglialcellsindifferentdegree,contracted,ingrained,swollenkaryon,themildexpansionedemaofthevascular,partoftheaeroelasticvascular,infiltrationofinflammatorycell,mildedemaofintercellular2摘要spaceinthehigh,medium,lowgroup.Comparewithmodelgroup,t
8、hehigh,medium,orlowdosegroupofpathologic
