pparγ在哮喘小鼠气道的表达与临床意义

《pparγ在哮喘小鼠气道的表达与临床意义》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、Results：1．Theperformanceandcomparisonandgroupbothapparentrestlessness，easilyofasthmamicemodel：themiceofacutefrightened，shortnessofbreath，wipenasal，sneezing，liptailpurplecyanosis，activityfrequently，furshadowbane，abdominalmusclespasm，incontinence，etc；chronicgroupshowedmoreespeciallynoticeable，t

2、herhythmofbreathingnotneat，fellmotionless，limbsundermines．normalgroupdidnotappearafore-mentionedsymptoms．2．Pulmonaryhistopathologicallyobservation：acuteandchronicgroupcomparedwithnormalgroupshowedlungsurfaceswelling，increaseinsize，CUt·sidevisibleoozywhitefoam．LungbiopsyHEdyeingappearbronchial

3、lumennarrow，mucosaedema，mucousglandularhyperplasia,mucousmembrane，thealveolareverythickening，edemairregularshape，thealveolarspacefusionexpanded．acuteGroupbronchialsmoothmuscle，bloodvesselsaroundthemucosaandsubmucosashowsinflammatorycellinfiltration；chronicgroupintheacutestageofthepathological

4、basisofthegassubepithelialfibrosis，gobletcellhyperplasia,airwaysmoothmusclecellproliferation，hypertrophy，airwaysmoothmusclecellmigrationandvascularremodelingandangiogenesis，je，airwayremodeling．Normalgroupnormalmouseairwaysandalveolarstructuresandbronchialepithelialintegrity，andnosignificantin

5、flammatorycellsandairwayremodelingchange．3，Airwaymorphologyanalysis：acute，chronicandnormalmiceoftotaltracheawallthickness(Wat／pbm)9．644-1．36pm2／pm，15．254-1．43btm2／btm，5．59--I：1．41pm2／pxn，chronicgroup’sWat／pbmmorethanacuteandchronicgroupwassignificantlyincreased(P

6、lysignificant；acutegroupofWa_t／pbmthannormalgroupwassignificantlyincreased(P

7、rencewasstatisticallysignificant，acutegroup’SWai／pbmmorethannormalgroupissignificantlyincreased(P<0．01)differenceisstatisticallysignificance；airwaysmoothmusclethickness(Warn／pbm)thickness，respectively，10．644-1．30I_tm2／1．tm，15．67士2．02pm2／Bm，5．