lcms%2fms在体内滥用药物分析中的应用

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1、dissociationreactionproductsofthesebarbitalswereproposed．LC—MS／MS，madditiontoitsspecificityandeasyuse,providedthedemotionlimits(10ng／mL)lowerthanthosereportedinmanyLCandGC—MSmethodsanddidnotrequirederivatization．8．Screeningfor132drugsandtoxiccompoundsinbodyfluidsusingLC—MS／MS

2、．MRMtechniqueoffershighsensitivityandstructuralinformationofscala，andthelimitsofdetectionforthemajorityofthecompounds(83％)≤lng／mL．TheresultsshowedthatMRMscreeningwasreliableandgenerallymoresensitivethanGC／MS．Themethodwassufficientlyselectiveandsensitivetodetectthedrugsdowntot

3、herapeuticconcentrationlevelsandiSthereforefeasibleinforensicandclinicaltoxicology,andthemethodmaybeadopttOotherbiologicalsamples．LC．MS／MSsolvedtheproblemsintheconfirmationofillicitdruguseusingGC—MStraditionally．Aboveall，thereweresomeinnovationsandsignificances．1．TheLC—MS／MSm

4、ethodsforthedeterminationofdrugclassescontainingopiates，amphetamines，THC—COOH，cocaine,hallucinogens，benzodiazepines，barbitalsandtheirmainmetabolitesinbiologicalsamples(blood,urineandhair)weredeveloped，ontheotherhand,Screeningfor132drugsandtoxiccompoundsinbodyfluidswasdevelope

5、d．AllthemethodsareforthefirsttimeinOral"country．2．TheLC—MS／MSmethodsweresimple，fastandeffective．Thesamplepreparedwithdilutionfollowedbydepositiondirectlyorliquid-liquidextractionsimply-Theliquidchromatographyt；eparatedwellanddecreasedtheionsuppressioneffectsofmatrixes．Theover

6、allturnaroundtimesforallthemethodswerefromthreetofourteenminutes．3．ThecompoundsfordetectingarelargeenoughthatcomprisingnotonlyillicitdrugsbutalsotheirmetabolitesinIx)dy．ThetargetsCanbeincreasedintheforensiccases．Thestudyenhancesthepossibilityofdetectingdragsandmeetstheneedsof

7、theproofinforensicsciences．4．Theanalyticalprocedurewashighlysensitive．Thelimitsofdetectionwereachieved0．01一lng／mL，comingtotheadvancedinternationalleveL5．Thebiologicalspecimensconsistedofblood,urine,hairandoralfluid．Thestudyhastheextremelyimportantpracticalvalue．Atthesalnetime

8、ithasforesightedness,manifestingthedevelopingtendencyinthefieldofour