er、pr、her2、ki67在乳腺癌原发灶及局部复发灶中表达差异的研究

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1、大连医科大学硕士学位论文TheStudyOiltheDifferentialExpressionsofER，PR，HER一2andKi67inPrimaryandLocallyRecurrentLesionsofBreastCancerMasterdegreecandidate：LiRuiSupervisor：ProfessorGuoWenbinMajor：SurgeryAbstractObjective：Positiveexpressionsofestrogenreceptor(ER)andprogestronereceptorfPR)along1IⅣiththeoverexpr

2、essionofHER一2oncoproteinareindicatorsdirectingbothendocrinotherapyandbiologictargetedtherapy．Ki67，anuclearantigenrelatedtothecellproliferation，isthemostreliableindicatorjudgingtheproliferativeactivityoftumorcells．Breastcancerisamultifactorialdisease，andtheremaybechangesinthemolecularphenotypeo

3、fbreastcancerafterrecurrenceandmetastasisasthecomprehensivetreatmentofbreastcancerisapplied．Today,aprimarylesionisthecriterionforjudgmentofgeneexpressionsofpatients、析threcurrentormetastaticbreastcancer,butitneglectsthepossibilityofchangeinexpressionsofER，PR，HER-2andKi67inrecurrentormetastaticl

4、esionofbreastcancelMethods：Aretrospectiveanalysiswasmadeon56patientswithlocallyrecurrentbreastcancer(24withchestwallrecurrence，13withipsilateralaxillarylymphnoderecurrence，17withipsilateralsupraclavicularlymphnoderecurrenceand2withipsilateralbreasttumorrecurrenceafterbreast—conservingsurgery(B

5、CS))admittedintheDalianMunicipalCentralHospitalfromJanuary2010toFebruary2013．Allpatientswereperformedsurgicaltreatmentsonfirstvisit；whentherewerelocalrecurrences，recurrentlesionswereperformedexcisionalbiopsyorcoreneedlebiopsy；pathologicalexaminationsconfirmedasrecurrentlesionsofbreastcancerwhi

6、chwereperformedimmunohistochemicaldetection；allcaseshadcasedataandarchivedparaffinspecimens．ExpressionsofER，PR，HER-2andKi67inprimaryandrecurrentlesionswereachievedbyimmuno-histochemistry．DifferentialexpressionsofER，PR，HER-2andKi67inprimaryandrecurrentlesionswereanalyzedbystatisticalmethods．Res

7、ults：Amongthe56patientswithlocallyrecurrentbreastcancer,69．6％ofthem(39／56)werefoundpositiveERinprimarylesions，30．4％ofthem(17／56)werefound大连医科大学硕士学位论文thatERsconvertedfromprimarylesions(positive)tolocallyrecurrentlesions(negative)，7．1％oft