dna修复基因多态与乳头状甲状腺癌的分子流行病学研究

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1、●英文摘要controlsinmalesubjects(z2=8．05，p-q)．018)；thegenotypeof2063T／AcouldreducetheriskofPTCwiththeORof0．36(95％CI=0．15·084，P--O．018)i11malesubjects，comparedwiththegenotypeof2063T／T．ItwasshowedthatthegenotypiefrequenciesforT30028Csiteweresignificantly&fferen

2、tbetweenPTCpatientsandcontrolsinmalesubjects(z2-7．20，P--0．027)；thegenotypeof30028T／CcouldreducetheriskofPTC、)l，imtheORofO．32(95％CI=0．14-0．75，P--0．008)，andthegenotypesof30028T／C+C／CcouldalsoreducetheriskofPTCWIththeORof0．35(95％CI=0．15_o．78，P=0．009)，inmale

3、subjects,comparedwiththegenotypeof300281压．6．nlemultivariatelogisticregressionmodelwasfittedwitllthevariablesofthepolymorphismsofnucleotldeexcisionrepairgenes，gender，age，dietsandotherenvironmentalfactors．Itwasshowedthatthegenotypeof19007G／AinERCClgene(OR=

4、207，95％CI=1．17·369，P=0．013)，thehistoryofreceivingCTdiagnosis(oR-10．49，95％CI=4．17·26．43，P--0．000)，eatingseafoodfrequently(oR=8．12，95％Cp3．oo-21．99，P---0．ooo)，eatmgpeanutsfrequently(oR=5．63，95％CI=1．82-17．41，P--0．003)andnegativellfeevents(OR=3．07，95％CI=1．19—

5、7．90，P--0．0201weretheriskfactorsofPTC；thatthegenotypeOf2063T／AillER(Y—gene(OR=0．43，95％CI=0．19-0．98，P=0．046)，drinking(OR=0．13，95％CI=0．03·0．60，P=0．009)，eatingfruitsfrequently(OR=0．50，95％C瑚．28-O．92，P=0026)，possessinghigherecenomiclevel20yearsago(OR=0．28，95％

6、CI=0．02—0．47，P=0．ooo)，drinkingteaoccasionally(OR=0．42，95％CI=0．23-0．76，P---0．004)，dnnklngteafrequently(OR=0．28，95％CI=0．12-0．67，P--O．004)，mother’sagenotmorethan22yearsoldwhensubjectbom(OI㈨．44，95％CI=o．20-O．96，P=0．039)andmother’Sagemorethan30yearsoldwhensubj

7、ectborn(OR=0．43，95％CI=o．21一O．87，P=0019)weretheprotectivefactorsofPTC．Afterthegender-relatedfactorswereputmtothemodelforthefemalesubjects，itWasshowedthegenotypeof19007G／AinERCCl(OR=286，95％CI一1．43·5．74，P---0．003)，thehistoryofreceivingCTdmgnos,s(OR=602，95％C

8、I=209-17．33，P=-0001)，eatingseafoodfrequently(OR=6．61，95％CI=1．84·2376，P=0．004)，eatingpeanutsfrequently(OR=294，95％CI=1．32·655，P--0．008)andnegativelifeevents(OR=4．59，95％CI=1．39—15．13，P=0012)weretheriskfactorsofPTC；thatthegeno