ct灌注成像对肺癌分子靶向治疗疗效的判定价值

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1、AbstractCTperfusionimaginginlungismainlyusedforthediagnosisanddifferentdiagnosisoflungnodulesandevaluatingthetherapeuticefficiencyforlungcancerwithradiotherapyorchemotherapy．Buttherelativestudyaboutitsusinginevaluatingthetherapeuticefficiencywithmoleculartargetedtherapyisless[：!】．Th

2、isstudyistoevaluatethechangeofmicroangioarchitectureandangiogenesisofthetumorthroughmeasuringandcomparingtheCTperfusionimagingparametersofthelungcancerbeforeandaftermoleculartargetedtherapy，andthentoevaluatethelivenesschangeoflungtumor,whichhelpclinicaldoctorsevaluatethetherapyeffic

3、iencyearlyandmakefurthertreatmentplanmuchbetter[6】．WeCanalsoevaluatetheCTperfusionimagingtechniqueinassessingtheefficiencyofmoleculartargetedtherapymeanwhile．Materialandmethods1、clinicaldate：43patientswithlungadenocarcinomaprovedpathologically。werecollectedinHenanTumorHospitalfrom20

4、10．10to2012．01，theepidermalgrowthfactorreceptor(EGFR)genemutationdetectionpositive．7patientsofthe43patientswereremovedbecauseoftheconstructeddefecteffectwhichinducedthefailureindateprocessing．Ofthefollowing36patients，14weremaleand22werefemale．Age48-79yearsold，averageagewasabout61yea

5、rsold．16ofthe36patientshadtakenchemotherapy、radiotherapyorotherantitumortherapy．Patientswithseriouscardiacdysfunctionandhepatic、renalinadequacywereremovedspecially．Allthe36patientsundertake2timesofCTPIexaminationwithMultisliceComputerizedTomography(MSCT)beforeandonemonthafterthemole

6、culartargetedtherapy．2、experimentdesign：AccordingtOthenewResponseEvaluationCriteriainSolidTumors(RECIST)，ofallthe36patients，16patientswereassessedpartialVIIAbstractremission(PR)aftermoleculartargetedtherapy，12wereassessedstabledisease(SD)and8wercassessedprogressivedisease(PD)⋯．Thise

7、xperimentdividedthe36patientsintoA，B、CgroupscorrespondingtothetherapeuticresultPR，SD，PD．ThechangeofalltheCTPIparametersofthepatientsofthethreegroupswereanalyzedandobtainedstatisticallyandcorrespondingly．TheevaluatingresultswithCTPIparametersandthataccordingtoRECISTwerecompared，andth

8、enthevalueofCTPIine