cox2和heparanase1在肾上腺肿瘤中的表达及临床意义

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1、硕士学位论文ExpressionandclinicalsignificanceofCOX一2andHeparanase一1inadrenaltumorsSpecialty：UrologySurgeryPostgraduate：ZhuChenhuiSupervisor：HuWeilieABSTRACTBackground：Inrecentyears，Withthecontinuousdevelopmentofmedicalsciencetechnology，especiallyinimaging(CT,MRI，etc．)andbiochemical

2、detectionmethodsofimprovedandpeople’Shealthycheck．upawarenessofcontinuousimprovement，therateofdiagnosisofadrenaltumorsisincreasingyearbyyear．Adrenaltumorsincludingadrenocorticaltumorsandadrenalmedullarytumors．Theadrenocorticaltumorscontainadrenalcorticaladenomaandadrenalcorti

3、calcarcinoma．Theadrenalmedullarytumorsaredividedintobenignpheochromocytoma，malignantpheochromocytomaandparaganglioma．Amongtheadrenocorticaltumors，adrenalcorticaladenomahasagoodprognosisandCanbecuredbysurgery,buttheadrenalcorticalcarcinomahasahigherdegreeofmalignancy，invasives

4、trong，earlydiagnosisanditstreatmentisstillradicalsurge渺-based，whilelacksofeffectiveadjuvanttherapy，especiallyintheearlystageitCallbetransfertothelung，lymphnodes，liver，bone，etc．itsannualincidenceofapproximately4to12permillionpopulation，5-yearSurvival<35％．Accordingtotheorganiza

5、tionalstructureandmorphologyoftheadrenalcorticalcarcinomaandadrenocorticaladenomaissimilar,SOtheidentificationofthebenignormalignantadrenocorticaltumorsisdifficult，andsometimesneedtocombinetheirclinicalmanifestations，grossspecimens，imagingandmicroscopichistopathologicalmorpho

6、logyandimmunohistochemistrytomakeacomprehensivejudgment．Atpresentthepathogenesisofadrenocorticaltumorsisnotclear,sometimesonlyaccordingtothehistopathologicalexaminationisdifficulttodeterminethedegreeofmalignancy，thusalotofhardshipcanbringtothetreatment．Atpresentthepathogenesi

7、sofPheochromocytomaisstillunclear．Sofarthediagnosisofmalignantadrenalpheochromocytomaisstillaccordingtothetumorinvasionofadjacentorgansormetastasistothewithoutchromaffintissueofchromaffincells．ThedegreeofTumorcelldifferentiation，suchasfilamentousmitoticactivity，nucleicacidpol

8、ymorphismandSOon，whicharenotapplytousedtodistinguishbetweenbenignand