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1、中文摘要目的：探讨热喘平口服液对实验性支气管哮喘豚鼠血清中超氧化物歧化酶（SOD）和丙二醛（MDA）含量的影响。方法：将50只豚鼠随机分成5组，每组10只，即正常对照组、哮喘模型组、地塞米松组、中药低剂量组、中药高剂量组。除正常对照组外，其余各组豚鼠均经腹腔注射卵白蛋白，并自注射14天起，对除正常对照组外其余各组进行卵白蛋白超声雾化，每日两次，建立哮喘模型。造模成功后开始灌胃给药，日一次，观察热喘平口服液对实验性支气管哮喘豚鼠血清中超氧化物歧化酶（SOD）和丙二醛（MDA）水平的影响，两种指标均采用均采
2、用ELISA酶标免疫分析法测定。结果：经热喘平口服液高剂量组治疗后豚鼠血清中SOD、MDA测定与正常对照组相比无显著差异（P＞0.05），中药高剂量组血清中SOD明显高于哮喘模型组、而MDA测定明显低于哮喘模型组，有显著差异(P<0.01)。结论:说明热喘平口服液能显著减少氧自由基的生成和释放，同时使气道慢性炎症得到抑制，因此，临床用药应以高剂量治疗为宜。关键词：热喘平口服液；哮喘；豚鼠；超氧化物歧化酶；丙二醛ThestudyofexperimentaboutRechuanOralliquidpairo
3、fexperimentbronchialasthmaguineapigsinwhichthecontentofSODandMDAAbstractObjective:TheinfluenceofreChuanPingOralMedicineoncontentofsuperoxidedismutaseandmalondialdehyde,whichinserumofexperimentalbronchialasthmaguineapigs,isexplored.Methods:Therandomdivide
4、s50caviesinto5group,10perset,Thegroup,highdosagesoftraditionalChinesemedicineformnamelytheregularcollationgroup,asthmamodelgroup,Dexamethasonegroup,lowdosagesoftraditionalChinesemedicine.Exceptcontrastingagroupregularly,theotherseverygroupcavygoesthrough
5、anabdominalcavitywithoutexceptionandstartingfrominjecting14dayinjectingovalbumin,theotherseverygroupgoalongovalbuminisfacetofacesuper-atomize,everydayexceptcontrastingagroupregularlytwice,buildtheasthmamodel.Begintoirrigatethestomachaftermakingamodelsucc
6、essfullytomedicine,Theonceeveryday,theinfluenceofreChuanPingOralMedicineoncontentofsuperoxidedismutaseandmalondialdehyde,whichinserumofexperimentalbronchialasthmaguineapigsisobserved.Thetwoparametersshouldusesandwichenzyme-immunoassayfordetecting.Results
7、:ThedeterminationofSODandMDAinguineapigs,thereisnoobviousifferencesbetweennormagroupsandafterhighdosagegrouptreatmentteamofreChuanPingOralMedicine（P＞0.05）,ThecontentofSODundertreatmentofchinesemedicineishigherthanasthmaticmodel,oncontrarythecontentofMDAu
8、ndertreatmentofislowerthanasthmaticmodel(P<0.01)。Conclusion:ShowsthatreChuanPingOralMedicinecandecreasedsignificantlyoxygenfreeradicals’sgenerationandreleased,asthesametimeinhibitthechronicairwayinflammation,therefore,clin
