epha22fephrina1与ecadherin在胰腺癌中的表达与临床意义

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1、中文摘要英文摘要前言····································……3正文····································……5材料····································……5方法····································……9结果····································……10讨论····································……24结论································

2、····……32参考文献····································……33综述····································……39致谢····································……48在读期间发表文章························……49英文缩写词索引···························……50复口.人学硕十论文EphAZ尼p一lrinAI及E一cadherin在胰腺癌中的表达及临床意义摘要【目的】探讨即hAZ、eph八nAI及l乙一cad比rin在胰

3、腺癌及下常JJds腺组织中的表达及临床意义。[方法]采用免疫组织化学[nV151。n二步法，检测通8例胰腺癌及}卜常肤腺组织中“p以2、叩hrin八1和卜cadherin的表达，并分析其与临床病理因素的关系。应用L。g一rank检验和COX比例风险模型分析EphAZ、ephrinAI和E一ead卜e:in的表达与患者预后的关系。【结果】巨p队2和ePhrinAI在胰腺癌组织和正常胰腺组织阳性表达百分率分别为83.3%和20.8%;85.魂%和35.刁%。E一Cadheri。在胰腺癌组织和正常胰腺组织高表达率分别为20.83%不「179.16%。胰腺癌中EphAZ、eph:1

4、nAI不rl阵Cadheri。的表达与患者年龄、性别、肿瘤部位、肿瘤直径及肿瘤分化程度等临床病理因素无相关性。随着胰腺肿瘤浸润深度的增加，巨ph八2和即hrin八l蛋白在T3一训的表达高于其在T卜TZ的表达，差异有统计学意义(只0.05);淋巴结转移组中即卜A2和I加卜r1nAI蛋白的表达高于无淋巴结转移组，差异有统计学意义(只0.05)。}厄l二一Czlc}heri。蛋自的表达则低于无淋巴结转移组，差异有统计学意义(只0.05)。按2002年第jl-版}l木J咦步I芍1办会(Jl，S)标袱L进行JJ中瘤分期，以l级、2级为弱阳性染色，3级为强I‘}」，卜!:染色，111一

5、I/期)]夷腺癌I三phAZ和ephri。AI强I泪性染色分别为d魂.12%和26.7、4%，高于卜!!)如的7.曰%和7.1魂%，(只0.05)。[一cadherin高表达与低表达患者术后生存率比较差异有统计学意义(只0.05)。COX多因素分析表明，巨phAZ阳性表达、卜c刊herin低表达和护S分期是反映胰腺癌预后的独立指标。[结论]巨phAZ、ephrinAI与E一Cadherin在正常胰腺组织和胰J泉J癌中表达有差异性，它们表达异常可能共同参与了胰腺癌的进展与转移:联合检测三种蛋白对于评价胰腺癌的预后有一定参考价值。[关键词]巨phAZ;ephri。AI;巨一e

6、adherin;胰腺癌:J尸S分期;预后【中图分类号】}花复口.人‘学硕十论文ExPressionandSignifieaneeofEPhAZ、EPhrinAIandE一eadherininPanereatieCareinomaAbstraetobjeetive:I、0investigatetherelationshipbetweenEphAZ、ephrinAIandI二一eadherinexPressionwithtumorstageandPrognosisinpanereatieCa门Cer.Methods:EphAZ、ephrinAIandE一eadherinexpr

7、essionweredeteetedbyimrnunohistoehernistryintumortissuesandnor阳altissuesPeeimensfrorn48easesofPrimaryPanereatieeaneer.Results:TheexpressionofEphAZandephrinAIwashigherinPanCreatleeare1nomatissuesthaninnormalpanereatietissues(P<0.05).巨一eadherinexprossionwaslower