l肉碱联合西地那非对糖尿病雄性大鼠生殖参数和勃起功能的作用的研究

《l肉碱联合西地那非对糖尿病雄性大鼠生殖参数和勃起功能的作用的研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、AbstraetTheeffectofL．．carnitinecombinedwithsildenafilonreproductiveparameteranderectilefunctionindiabeticmaleratsAbstractObjective：ThisstudyinvestigatedthetherapeuticeffectsofL-carnitine(LC)andsildenafilaloneorcombinedtreatmentonreproductiveanderectilefuncti

2、onindiabeticmalerats，andexploreditsmechanismfromhormoneandoxidativestress,toprovideexperimentalevidenceforthetreatmentofLCcombined、航tllsildenafilonreproductiveanderectilefunctionindiabetes(DM)Methods：ToestablishType2diabeticratmodelbyinjectionofsaline，groupB

3、(DMmodel)：saline，groupC(S)：5mg／kgsildenafilsolution，groupD(LC)：300rag／kgLCsolution，groupE(S+LC)：5mg／kgsildenafil+300mg／kgLCsolution．Afterthelastadministration，observederectilefunctionstatusbyapomorphinetestanddetectionofintracavernouspressure(ICP)；thentherat

4、swerekilled，wetookthetestis，epididymis，penisandobservedtheStatusofspermcount,viabilityincaudaepidid)，midisandapoptosisofspermatogeniccellandthechanges’ofmalondialdehyd-e(MDA)，superoxidedismutase(SOD)andtotalantioxidantcapacity(TAC)intestis，epididymis，penisan

5、tioxidantcapacity(TAC)intestis，．epididymis,penis；tookbloodfromhearttodetectthechangetestosteronefr)，folliclestimulatinghormone(FSH)，luteinizinghormone(LH)．Results：TheresultofAPOexperimentshowedthaterectiletimesofratsinallgroupwasnosignificantdifferencebefore

6、theexperiment．Attheendofexperiment,withthetherapyofsildenafil，LCandtheircombination，theerectiletimesandICPofratsincreasedsignificantlythanDMmodelgroup，alsothereWasmoresignificantincreasebetweenthecombinationandalone、衍msildenafilandLCinerectiletimesandICP．Rep

7、roductivefunctiontestresultsrevealedthatthespermcountandviabilityincaudaepididisafteraloneandcombinationtherapyofsildenafilandLCwererosethanDMmodelgroup，andthecombinationtherapywasbetterthanalonetherapy．Intheaspectofapoptosisofspermatogeniccell，comparedwithD

8、Mmodelgroup，groups谢也combinationandaloneofsildenafilandLCweresignificantdecreased，andthecombinationtherapygroupWasmoresignificantdecreasethanalonetherapygroup．Inreproductivehormonesecretion，compa