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1、新疆医科大学硕士学位论文RelationshipbetweenRASchangesandhepaticfibrosisindicewithhepaticBandhepaticcirrhosisPostgraduate:liuweiyingSupervisor:AssociateprofessorxiaolinAbstractObjective:TOexploretheexpressionlevelofAGT,AngIIandACE,intheRAS,relationshipwiththehepaticfibrosisindicesi
2、nthehepatitisBvirusandhepaticcirrhosispatients.Methods:180casesoftheobjectofstudy,thenormalcontrolgroup,themildhepatitisgroup,themoderatehepatitisgroup,thehepaticcirrhosisgroupwere30cases,30cases,30casesand90cases,respectively.TheELISAandchemiluminescentimmunoassaymeth
3、odwereadoptedtodetectAGT,AngII,ACEandliverfibrosisindices.Results:1.WiththediseaseprogressestheHA,LN,PCIII,IV-C,AGT,AngIIandACEriselevels,comparisionwiththehepaticcirrhosisgroupwassignificantlyhigherthanothergroups(P<0.01orP<0.05).2.ComparisionintermsofAGT,differencefr
4、omtheChild-PughAclassandthenormalcontrolgroup,theChild-PughBclassandthenormalcontrolgroupthedifferencewerestatisticallysignificant(P<0.01,P<0.05,respectively);comparisionintermsofAngIIandACE,differencefromtheChild-PughCclassandthenormalcontrolgroupthedifferencewerestat
5、isticallysignificant(P<0.05).3.ComparisionintermsofAGT,differencefromthenoascitesgroupandthenormalcontrolgroup,theascitesgroupandthenormalcontrolgroupthedifferencewerestatisticallysignificant(P<0.01,P<0.05,respectively);comparisionintermsofAngIIandACE,differencefromthe
6、ascitesgroupandthenormalcontrolgroupthedifferencewerestatisticallysignificant(P<0.05).4.ComparisionintermsofAGT,differencefromthenohepatorenalsyndromegroupandthenormalcontrolgroupthedifferencewasstatisticallysignificant(P<0.05);comparisionintermsofAngIIandACE,differenc
7、efromthehepatorenalsyndromegroupandthenormalcontrolgroupthedifferencewerestatisticallysignificant(P<0.05).5.TheAGT,AngII,ACEmentionedwerenolinearcorrelationwithhepaticfibrosisindexes(P>0.05).Conclusion:WiththeprogressofthehepatitisfibrosisincreaseinplasmaAGT,AngIIandAC
8、E,butit’snocorrelationwith2万方数据新疆医科大学硕士学位论文hepaticfibrosisindices.JudgementthechangeofchronichepatitisBpatients,dynam