心室功能和心肌损伤的分子影像分析

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1、北京协和医学院中国医学科学院硕士研究生学位论文Additionally,thetissueareapositivefor99mTc-Duramycinwas23．7士6．1％greaterthantheinfarctsizeasdeterminedbyautoradiographyversustetrazoliumstaining．Conclusion：Theinvivopropertiesof99mTc．Duramycinaresuitableforapositiveimagingagentfordetec

2、tingacutecelldeathintheheart．Thecurrentinvestigationusinganestablishedlargeanimalmodelmarkedanimportantmilestonetowardclinicaltranslation．KeyWords：Duramycin，phosphatidylethanolamine，ischemia-reperfusioninjury,apoptosis9AbstractPart2Comparisonof蜘Tc．MIBISPECT

3、／18F-FDGPETimagingandcardiac嗽gneticresonanceimaginginpatientswithidiopathicdilatedcardiomyopathy：assessmentofcardiacfunctionandmyocardialinjuryObjective：Theaimofthisstudyistoevaluatetheagreementbe铆eenmyoc删1砒18F．FDGPETim啦gandcardiacmagneticresonanceimaging(c

4、M融)inassessingcardiacfmlctionaIldrelationsllipofcMRIlate—gadoliniumenhancement(cMlU_LGE)andmyocardialperfusion．metabolismpatterninpatientswithidiopathicdilatedcardiomyopathy(IDCM)·．Methods：42consecutivepatientsdiagnosedwithIDCMwereenrolled·Allpatientsunde刑e

5、nt99mTc．MIBISPECT，gated18F-FDGPETimagingandcMRlwithin3·7days·Cardiac劬ctionparameterswerecalculatedusingPETandcM_R_I·ThesegmentsanalvsiswaSperformedusing17．segmentmodel．Patternsofperfusion／metabolismwereclassifiedasnonnal，mismatch，mild-to-moderatematchandsev

6、erematch，andcMRI．LGEWasclassifiedinto3categories(non-LGE，mid。wallLGEandtransmuralResuIts：nlecorrelationbe如陀engatedPETandcMRlwasexcellentforEDV(r=0·948，P<0．001)，ESV(r=0．939，P<0．001)andLVEF(r=0．685，P<0．001)．EDVandESVwereunderestimated，whereasLVEFWasslightlyov

7、erestimatedbygatedPETincompansontocMRI．Perfusion／meta_bolismpatternsvariedinthreedifferentcategoriesofnon-LGE,mid．wallLGEand缸ansmuralLGE(Z=14．276，P<0．001)．71．o％(44／62)segmentswlthmid．wallLGEhadnomalperfusion／metabolismpatterns，and75·9％(63／83)per向sion／metabo

8、lismmismatchsegmentswereshownnon—LGE．TheincidenceofLGEwassignmcantlyhigherinsegmentswithseverematchthanother3se舯entgroups(Z2=112．53，P<0．001)．Conclusion：ThereisanexcellentagreementbetweengatedPETandcMRI