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1、宁夏医科大学硕士学位论文英文摘要(2)AfterTFLBprotection,comparedwiththeHGinjuredmodelgroup,theamountofreleaseofMDAintheTFLBprotectivegroupsobviouslydecrease,theamountofreleaseandactivityofLDHdecreases,SODactivityincreasesobviously,NO,NOSgenerationandtheactivityallincreaseobviou
2、slyandthedifferenceissignificant(P<0.05,P<0.01),andthemedlarflavonesshowsdosedependentrelationshipinacertainconcentrationrange.(3)AfterTFLBprotection,comparedwiththeHGinjuredmodelgroup,sTMinmedlarflavonecontentsshowsadecliningtrend.VWFandsEPCRcontentareonthedec
3、line,andthedifferenceissignificant(P<0.05,P<0.01).2.Usingin-vivoassaystoresearchflavonoidscompoundsfromlyciumbarbarum’sprotectionfrominjurymodelofdiabetesmellitus（DM）ratinducedbystreptozocin.(1)AfterTFLBprotection,TFLBcandelaythecourseofTheriseofbloodglucose,ha
4、veobvioustrendtodecreasethelevelofblood-lipid.(2)AfterTFLBprotection,comparedwiththeDMmodelgroup,vWFandsTMandsEPCRdeceasesineveryTFLBgroupsandthedifferenceissignificant(P<0.05,P<0.01).(3)AfterTFLBprotection,comparedwiththeDMmodelgroup,withtheincreasingofTFLB,is
5、letnumberandnumberofsecretorycellsincreaseinrat,celllineagerelativelyuniformneat,isletstructureandformbasicreturnstonormal,andrelativelylessofcellsshowvacuolesdegeneration.(4)AfterTFLBprotection,comparedwiththeDMmodelgroup,theaorticintimaininTFLBcontentinlowgro
6、upthickensobviouslywithmountain-likeprotrusions.Therearevascularmorphologychangesandunevenchangesofthicknesswithpartlyvisiblepatches.Outermembranehasmilddamage,endothelialcellshaveproliferatedandstillnotneat.TheaorticintimaininTFLBcontentinhighgroupthickensmild
7、lyV万方数据宁夏医科大学硕士学位论文英文摘要endothelialcellshaveproliferatedmildlyandarrgmgeneatandoutermembranehasnoobviousdamageConclusion1.AftertheprotectionofTFLBfrominjurymodelofHUVECinducedbyHG,theactivityofantioxidantenzymes(SOD)inHUVECwasimproved,thegeneratingcapacityandthe
8、activityofNOandNOSwasincreased,thegeneratingcapacityofMDAandLDHwasdecreased,thecontentofvWF、sTM、sEPCRofvascularendothelialfunctionwasreducedandachievedtheprotectionofvascula
