ss—ⅱ型脊髓打击器的研制与标准化脊髓挫伤动物模型建立

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1、《》=!：，盘惫，霪硕士学位论文豁一Ⅱ型脊髓打击器的研制与标准化脊髓挫伤动物模型建立DesignofSS-IIMultifunctionalElectromagneticImpactDeviceSystemandDevelopmentofStandardizedAnimalSpinalCordContusionModeIDepartmentofOrthopedics，SecondAffiliatedHospital，SunYat-senUniversityMajor：SurgeryName：HUANGLinSupervisor：ProLSHENHui-yongAbstra

2、ctBackgroundAnreliableandreproducibleanimalmodelofspinalcordtraumaisessentialforunderstandingtheinjurymechanismsandtoaidthedevelopmentandevaluationofnewtherapeuticmodalities．Themostcommonmethodforproductionofspinalcordinju叭SCI)istheweight-dropmethod．Thefirstwell-controlledanimalmodelofspi

3、nalcordinjurybyusingaweight-droptechniquewasdescribedbyAllenin1911．InvestigatorshavemodifiedanddevelopedanimalmodelsofspinalcordcontusioninanaRempttoreproducevanousaspectsofbiomechanicalresponses，neurologicaldefioits，andpathoIogy．However，mostofthesemodifiedimpactoroverseaareexpensiveandse

4、ldomUSEinChineseresearchunits．Furthermore．almostalloftheseimpactordevicesareconfinedemployedinrodentsmodelandcannotbeusedinlargeanimalsuchasnon-humanprimateorpig．0bjectives1．Todesignanddevelopanewimpactdevice‘》￡，忠：曼!硬士学位论文疆一Ⅱ型脊髓打击嚣的研制与标准化脊髓挫伤动物模型建立characteristicwithmutiifunctionalandelect

5、romagneticcontrd．Andtoestimateperformanceofthedevice．2．TodevelopareliableandreproduciblestandardizedgradedcontusiveSCImodelinratsandconsistencyunilateralthoracicspinalcontusionmodelindomesticpigwiththeSS-IIimpactdevice3．Toinvestigatetheeffectofthedegreeofimpactenergyollthefunctionaloutcom

6、eandhistopathologicfindingsoftheSCImodel．MATERIALSANDMETHODSI一)DesignoftheS8·11multifunctionalelestromagnetlcIm∞ctdevicesystemAccordingtothepdndpleofweights-droppingandelectromagneticcontrol，designandproduceanewuniversalimpactdevicesystem．I二lDevelopmentofStandardizedGradedAnimalSpinalCord

7、ContusionModelusingSS-"如1pactdevkesystemSubjects1．Atotalof50femalesprague-Dewleymrsevemgeweighing222．6-±18．279wereused．Animalswererandomlydistributedtothethreeexperimentalandonecontrolgroups．TheanimalsreceivedTIOlaminectomyandweredividedinto3experimentalgroupsaccord