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1、TheinfluenceofDHAenricheddietsonvascularfactorsinmousemodelsforAlzheimer’sDiseaseAuthor:DaanvanRooij1,2Supervisors:Dr.A.Kiliaan1,2D.JansenM.Sc1,2Affiliations:1Dept.Anatomy,2Dept.CognitiveNeuroscience,RadboudUniversityNijmegenMedicalCentre,Nijmegen,TheNetherlandsC
2、orrespondence:D.vanrooij@student.ru.nlKeywords:Alzheimers’Disease,vasculature,DHA,ApoE,APP/PS123Abstract:ADisoneofthemostcommonneurodegenerativediseasesintheindustrializedworld,andatthemomentthereisnoavailablecureforthedisease.Inrecentyearspreventiveinterventions
3、havecomeintofocus.Inspecific,dietaryinterventionsutilizingpolyunsaturatedfattyacidssuchasDocosahexanoicacid(DHA)havebookedpromisingresults.GiventhecloserelationbetweenADriskfactorsanddevelopmentandotherneurovasculardisorders,itishypothesizedthattheinfluenceofDHAe
4、nricheddietsworksprimarilybyimprovingcerebralbloodvesselhealth.Inthisexperiment,theinfluenceofputativedietssupplementedwitheitherDHAorcholesteroloncognitiveperformanceandcerebralperfusionareinvestigatedforboththeclassicalADmodel,APP/PS1mice,aswellasfortwomodelsof
5、vascularfactorsinAD,theApoE4andApoEKOmiceat10-12monthsofage.OurresultsshowthepredictedcognitiveimpairmentsofAPP/PS1andApoE4,butnotforApoEKOmice.Cerebralperfusionisfoundtobeimpairedinallthreetransgenicgenotypes,mostnotablyintheAPP/PS1andApoEKOmice.Noconsistenteffe
6、ctsofourdietaryinterventionarefound.FromthisweconcludethatApoE4andApoEKOmiceareavalidmodelforvascularADfactors.Wealsoconcludethattheeffectsofpreventivedietaryinterventionsarenotyetvisibleattheearlystagesofdiseaseprogression.IntroductionAlzheimer’sDiseaseAlzheimer
7、’sDisease(AD)isoneofthemostcommonneurodegenerativediseasesinwesternsociety.Anestimated15millionpeopleworldwidesufferfromADatthistime(Alz.Org.2009).Inthecomingdecades,increasesintheaveragelifeexpectancywillarguablyleadtoanevengreaterimpactofADonoursociety.Theincid
8、encerateofADintheUSwas411.000casesintheyear2000(Alz.Org.2009),afigurethatisestimatedtoincreaseto615.000intheyear2029.ADischaracterizedbyneuronaldysfunctionandn
