基于mri的健康成人与帕金森病人的纹状体体积测量分析

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1、浙江大学硕士学位论文MRIStudyofStriatumVolumeInHealthyAdultsandEarlyParkillS0niallPatielltSMediealCollegeofZhejiangUniversityDePartmentofRadiology2006GradeMaster，5CandidateXuJingfengSuPervisorProf.ZhangMinmingAbstraetBaekgroundandPurPose:Thestriatum，ineludingthecaudatenueleus

2、andPutamen，15themajoreonstruetionofbasalganglia，andthemostimPortantPartofthedeePgraynuelei.Itpartieipatesinmotion’5Planing、exeeutionandeontrol.ResearehessuggestedthatthestriatumhadsomefunetionalandstrUeturalehangesintheneuraldegenerationdiseasesandloeomotordisease，

3、suchasParkinsondisease(PD)andHuntingtondisease(HD)，etal.50fartherewasstilllackofearly，effeetiveandobjeetivediagnosticmethod.MRimagingteehniqueseannotonlyProvideaninsightintothefunctionalchangesofthestriaturninbothhealthyandpathologiestatus，butalsoProvideaninsightin

4、tothesubtileanatomystrueturalehanges，anditcanProvidemo印hologysimulationandvolumecaleulationWiththecomPuter’shelp.ThisprovidedusanoninvasivemethodofresearchinghumanstriatuminvivotogetafullunderstandingofthestruetUralehangesinbothhealthyandpathologiestatus·Nowtherewa

5、snodetailedstlueturaldateofstriatumforrefereneeoftheChinese，weealeulatedthevolumesofthestriatum，andanal邓edtheeffeetofageandsexonthevolumeofthestriatumbasedonhealthyChinesebrainMRI，andalsoeomParedthedatawiththatofPDPatientstoinvestigatethePossiblebrainstruetureehang

6、esofPDinearlystage.浙江大学硕士学位论文MaterialsandMethodS:1.Subjeets:1.1Fiftyhealthyvolunteers，agerangedfrom18to70years，were脚upedas18~30years、31~40years、41~50years、51~60years、61一70years.EaehgrouPhad10PeoPle，whiehwaseomPosedof5womenand5men.AlleliniealassessmentineludingPhysi

7、ealexaminations，laborato尽examinations，ehestXray，汕do而naluxtrasoundexam，adetailedPsyehiatrieandmediealhistory，andmentalstatewerenormal.ThestudywasaPProvedbytheloealresearchethieseommittee，andallthesubjeetsgavetheirinfornledwritteneonsent.1.2TenPDPatientsinearlystagew

8、erereeruited(5women，5men，meanage:64.5years).ThePatientshadl一3year，5Parkinsonismhistory.ParkinsoniansymPtomswereassessedwiththeHoelinandYahrdisabi