肺结核性与腺癌性胸水的比较蛋白质组学分析

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1、中文摘要C4-B的含量高于肺结核性胸水，plasmaretinol—bindingprotein、Alpha-1一antitrypsin的含量低于肺结核性胸水；4．拉曼光谱分析可用于肺结核性胸水与肺腺癌性胸水的辅助鉴别诊断，肺结核性胸水的拉曼强度高于肺腺癌性胸水，胸水拉曼峰(1282．74cmd)的出现可作为肺腺癌性胸水的辅助诊断指标，诊断的灵敏度为68．75％，特异度为84．61％。关键词：胸水肺结核肺腺癌蛋白SDS-PAGE双向电泳质谱拉曼光谱IV硕士学位论文AStudyonAssociatedPleuralFluidProteinsofLungTuberculosisandL

2、ungAdenocarclnomabyC0mDaratlVe‘一●’—1J●ResearchbackgroundProteomicAnalysisMasterCandidate：XiaoShanshanSupervisor：Prof．ShenHongABSTRACTPleuralfluid(PF)oflungtuberculosisandlungadenocarcinomisthemostcommontwokindsofpleuralfluid．Atpresent，thediagnosisofPF,mostlyusesthemultiobjectiveexaminationgene

3、ralizedanalysismethod．Buteachl【iIldoftarget’ssensitivityandthespecificityaredifferent．Thenearly20％hydrothoraxoftubercularsandthecancerouspleurisycause，wasstillverydifficulttodistinguishaftertheoverallcheckinclinical．ItisanodusinclinictohowtodistinguishthetwokindsofPESDS-PAGEisunderelectricfiel

4、dfunction,accordingtotheproteinsubunit’Smolecularweightsizetoseparateprotein．SDS-PAGEnowdayshasbeenusedintheseperationofurineandblood，anddistinguishingcorrelateddiiseasebycontrastingelectrophoresisstraps．TherealenoreportsonSDS—PAGEusedtoseparatePEPleuralfluidcontainsplasmaproteinandproteincome

5、dfromlung．PFoflungtuberculosisandlungadenoearcinomalsocontaindefinitedproteinscomingfromeachdiseae．ThepreviousresearchwasrelatedtothechangeofsomekindofproteininthetwokindsofPETherearenocomparativestudyontotalproteinsinthetwokindsofPF．Theproteingroup’Sstudydevelopmenthasprovidedtheverygoodtechn

6、ologyplatformforthebodyfluidresearch．ProtiomicsresearchABSTRACTonbodyfluidsuchasbloodplasma,bloodserum，cerebrospinalfluid，urine，salivaisdeveloptingvigorously．Atpresent,thegroup’Sstudyresearchregardingthebodyfluidproteinisontherise．Therearemanygroupstudyresearchesonthebloodplasmaorthebloodserum

7、protein．ThereareveryfewreportsOilthehydrothoraxproteingroupstudybothindomesticandinforeign．Althoughhydrothoraxingredientissimilarwiththebloodplasma,stillmanydifferencesispresent,becauseofthoraciccavitydiseaseshavingtheirself'sfeature．Th