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ID:32025540
大小:17.01 MB
页数:74页
时间:2019-01-30
《脑胶质瘤新生血管变化特征与动态对比增强磁共振成像实验-研究》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、万方数据第三军医大学硕士学位论文bnoma·aSSOClaten州e0VaSCUlanZanonJⅥeaSUrenWltn一■●●J1lT1●●●l-●●J■BackgroundsDynamicC0ntrast-enhancedMRJAbstractG1iomaisoneofmemostag孕essiVenlmorinhumallity,11iglllyprolif.eratedneoVascularisoneofitsdistincthallmark.NeoV弱cularizationdescribestllep
2、rocesstllattumorgainblOOdsupply’preViouslyr印onedpan锄sofneoVasculaIizationincludingVascularco-option,a11舀ogeIlesis,V嬲culogenesis,mosaicVesselfomation,VascularmimicryaIldendoⅡlelialcelltransdifrerentiation.Glioma—aSsociatedneoVascul撕zationchangesrapidlyd谢ngtumor
3、progression,anddifrerentpatteHlsofneoVascularizationshowVanoussensitiVit)rtoaIltian百ogenicdrugs,thusinVestigationofdyllamicchaIlgesaboutmesepattemswillmal(eapositiVepromotionin舀iomatherapy.MagncticresonanceiIlla百ngisanon-inV嬲iVeima百ngtoolw11ichcanproVideinside
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5、ascularco·option,IMGa11dvaScularmimicryareassociated埘thgliomapro铲ession.Inthisanicle,weinVestigatedmepan锄sofneovaScul耐zationusiIlgd”amiccontrast—enhaJlcedMRI,aIldexploreditsutilityind锄ons仃{ningglioma-associatedneovascularization.MaterialsandMethodsWeusedtl鹏edi
6、fIj.erentgliomacell1ines,i.e.C6,U87,U25ltoestablish锄imalmodel,whileDCE—MRIaIldT2一WIMRlweretakentome嬲uredyn肌icchangesof酉ioma—associatedneovaseularization.1.EstablishmentofC6,U87,U251model:Theneedleofmicrosyringed印thof5mmaJld1×106resuspendedin10肛LDPBSwas蜥ected2.
7、SunriValanalysis:TbtalsuⅣiValtimeofeacht岫orbearinga11imalwasobtaineda11d万方数据第三军医大学硕士学位论文tllesuⅣ1Valratewasals0a11alyzed.3.PathologyinVestig撕on1).usingHEstainingtoinVestigatecharact耐sticof百iomap柚ology;2).CD34,TNCa11dPAS-CD34i衄uIlollistochenlis时metllodwasusedto锄
8、alyzedpattemsof舀ioma—associatedneoVasculadzation.3).Ⅱ一SMA,Desminstainingw嬲llSedt0comparet11ematurityofneovascularization.4).PCNA,MMP一2aIlalysiswasmadetoobseⅣewhetherdi仃erentpatt锄so
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