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ID:32023070
大小:3.82 MB
页数:60页
时间:2019-01-30
《颈动脉斑块积分与冠状动脉粥样硬化病变严重程度的相关性-研究》由会员上传分享,免费在线阅读,更多相关内容在教育资源-天天文库。
1、摘要冠状动脉粥样硬化性心脏病是一组以冠状动脉粥样硬化为主要病理基础,并引起冠状动脉管腔内斑块形成,或因功能(如血管痉挛等)因素,导致管腔狭窄或阻塞,引起心肌缺血缺氧,最终导致心肌坏死的症候群,严重威胁我国人民的身体健康和生活水平。有研究表明,颈动脉粥样硬化与冠状动脉粥样硬化性心脏病及脑梗死等心脑血管事件之间存在密切联系,因此,能否通过对颈动脉粥样硬化程度的评价间接反应冠状动脉的病变情况,是目前研究的热点。目的探寻颈动脉粥样硬化,特别是颈动脉斑块相关参数与冠状动脉粥样硬化性心脏病严重程度之间的关系。方法选取207例经冠状动脉造影确诊为冠心病的患者,依
2、据造影结果的病变血管支数分为单支病变组、双支病变组及多支病变组,收集其一般临床资料及颈动脉超声检查结果,并计算反映颈动脉斑块的Crouse积分和等级积分,以及反映冠状动脉病变严重程度的Gensini积分和Leaman积分,并对两者相关性进行比较。结果各组间性别比例、体重指数、总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、吸烟等指标均无统计学差异,但平均年龄、糖尿病患者及斑块检出率方面,双支病变组及多支病变组高于单支病变组(P3、ini积分及Leaman积分呈逐渐升高趋势;Crouse积分与Gensini积分(严0.455,P<0.01)和Leaman积分(r=0.358,P<0.01)均呈正相关。不同性别间比较,女性患者中,Crouse积分仅与Gensini积分呈正相关(产O.343,P<0.05),与Leaman积分之间无明显统计学相关性(产0.242,P>0.05),而男性患者中,Crouse积分与Gensini积分(严0.194,P>0.05)和Leaman积分(r=0.153,P>0.05)均未呈现明显统计学相关性。结论颈动脉斑块评分与冠状动脉粥样硬化严重程度存在4、相关性,颈动脉斑块积分,如Crouse积分可以基本反映冠状动脉粥样硬化严重程度。不同性别间,女性患者颈动脉粥样硬化程度与冠状动脉粥样硬化程度相关性较强。关键词冠状动脉疾病,颈动脉疾病,动脉粥样硬化,超声检查AbstractCoronaryarterydiseaseisasyndromewhichbasedonatherosclerosis,thenleadingtoplaqueformationorspasm.Asitsprogression,stenosisorocclusionofcoronaryarteriesresultinhypoxiao5、fmyocardium,finallydevelopedintothemyocardialinfarctionandevendeath.Recently,severalstudiesimplicatedthatatherosclerosis,thebasisofcoronaryarterydiseases,isasystematicprocedureandthereWasarelevancebetweencarotidatherosclerosisandcoronaryatherosclerosis.Somanystudiesfocusonwhet6、hercarotidatherosclerosisCanbeagoodsurrogatemarkertocertificatetheseverityofcoronaryarterydisease.That’Swhatweareinterestedin.Purpose:Carotidultrasonographyisoneofthemostefficientmethodstoevaluateatherosclerosis.Thisstudyaimstoclarifytherelevancebetweencarotidplaqueandthesever7、ityofcoronaryarterydisease.Methods:Subjectswere207patientswhounderwentcoronaryangiographyanddiagnosedcoronaryheartdisease.Patientsweredividedintothreegroups,one-vesseldisease(1VD),two-vesseldisease(2VD)andthree-or-morevesseldisease(3VD)bythenumberofvesselsinvolved.Physicalfind8、ings,biochemistrydataandcarotidultrasonographicdata,likeCrous
3、ini积分及Leaman积分呈逐渐升高趋势;Crouse积分与Gensini积分(严0.455,P<0.01)和Leaman积分(r=0.358,P<0.01)均呈正相关。不同性别间比较,女性患者中,Crouse积分仅与Gensini积分呈正相关(产O.343,P<0.05),与Leaman积分之间无明显统计学相关性(产0.242,P>0.05),而男性患者中,Crouse积分与Gensini积分(严0.194,P>0.05)和Leaman积分(r=0.153,P>0.05)均未呈现明显统计学相关性。结论颈动脉斑块评分与冠状动脉粥样硬化严重程度存在
4、相关性,颈动脉斑块积分,如Crouse积分可以基本反映冠状动脉粥样硬化严重程度。不同性别间,女性患者颈动脉粥样硬化程度与冠状动脉粥样硬化程度相关性较强。关键词冠状动脉疾病,颈动脉疾病,动脉粥样硬化,超声检查AbstractCoronaryarterydiseaseisasyndromewhichbasedonatherosclerosis,thenleadingtoplaqueformationorspasm.Asitsprogression,stenosisorocclusionofcoronaryarteriesresultinhypoxiao
5、fmyocardium,finallydevelopedintothemyocardialinfarctionandevendeath.Recently,severalstudiesimplicatedthatatherosclerosis,thebasisofcoronaryarterydiseases,isasystematicprocedureandthereWasarelevancebetweencarotidatherosclerosisandcoronaryatherosclerosis.Somanystudiesfocusonwhet
6、hercarotidatherosclerosisCanbeagoodsurrogatemarkertocertificatetheseverityofcoronaryarterydisease.That’Swhatweareinterestedin.Purpose:Carotidultrasonographyisoneofthemostefficientmethodstoevaluateatherosclerosis.Thisstudyaimstoclarifytherelevancebetweencarotidplaqueandthesever
7、ityofcoronaryarterydisease.Methods:Subjectswere207patientswhounderwentcoronaryangiographyanddiagnosedcoronaryheartdisease.Patientsweredividedintothreegroups,one-vesseldisease(1VD),two-vesseldisease(2VD)andthree-or-morevesseldisease(3VD)bythenumberofvesselsinvolved.Physicalfind
8、ings,biochemistrydataandcarotidultrasonographicdata,likeCrous
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