脑胶质瘤中ndrg2表达下调机制的研究

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1、脑胶质瘤中NDRG2表达下调机制研究研究生：周彬学科专业：神经病学所在单位：第四军医大学西京医院神经内科导师：邓艳春教授（主任医师）资助基金项目：国家自然科学基金NO.30672168关键词：神经胶质瘤；NDRG2；甲基化；PI3K；AKT2；PKC-α中国人民解放军第四军医大学2008年05月第四军医大学硕士学位论文目录缩略语表·························································································································

2、····················1中文摘要·············································································································································3Abstract················································································································

3、······························5前言·············································································································································8文献回顾············································································································

4、·································9一．NDRG2基因功能研究进展·····························································································9二、抑癌基因与肿瘤的关系·································································································111.抑癌基因与肿瘤形成之间的关系·················

5、·······························································112.抑癌基因发挥抑癌功能的主要途径·············································································11三、抑癌基因失活的主要原因·····························································································131.抑癌基因的缺失·········

6、···································································································132.抑癌基因编码区的突变································································································133.抑癌基因启动子区的点突变······························································

7、··························134.抑癌基因调控区的甲基化····························································································145.抑癌基因的失活与去乙酰化的关系·············································································166.PI3K介导的信号转导通路································