虎杖苷对大鼠低压低氧性肺动脉高压的预防作用与其机制-研究

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1、第四军医大学硕士学位论文2.1一般状况观察.....................................................................................382.2血流动力学指标.................................................................................382.3右心肥厚指数....................................................................

2、.................392.4肺血管组织形态学检查.....................................................................402.5血清、肺组织中NO含量及NOS活性...........................................433讨论.........................................................................................................44

3、3.1虎杖苷对低压低氧性肺动脉高压的预防作用及机制探讨.............443.1.1虎杖苷对模型大鼠一般情况的影响..........................................443.1.2虎杖苷对模型大鼠血流动力学的影响......................................443.1.3虎杖苷对模型大鼠右心室重构的影响......................................453.1.4虎杖苷对模型大鼠肺血管重建的影响.............................

4、.........453.1.5虎杖苷对模型大鼠肺组织和血清中NO含量及NOS活性的影响....473.2关于动物模型的评价.........................................................................493.3关于阳性对照药的选择.....................................................................514问题与展望...................................................

5、..........................................524.1存在问题.............................................................................................524.2展望.....................................................................................................535研究结论...................

6、..............................................................................53参考文献..............................................................................................................55个人简历和研究成果.........................................................................

7、.................67致谢..............................................................................................................68第四军医大学硕士学位论文缩略语表缩略词英文全称中文全称cNOSconstitutiveendothelialNOS结构型一氧化氮合酶HAPEhighaltitudepulmonaryedema高原肺水肿HPHhypoxicpulmonaryhypertension低氧性肺动脉高压HPVhy

8、poxicpulmonaryvasoconstriction低氧性肺血管收缩MAmuscularizedar