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1、芪黄勇安汤对断肢(指)再植和组织移植术后造血功能及免疫功能影响的临床研究中文摘要2)芪黄勇安汤能够优化血液流变学的各项指标，促进患者血液通畅，改善患者再植肢体的血运效率，提高再植肢体的成活率。3)芪黄勇安汤能够上调断肢再植患者术后bFGF和VEGF，促进肢体连接部位新生血管的产生，改善再植肢体的血供。4)断肢(指)再植手术后，芪黄勇安汤促进TLR4和TLR9受体的表达，开启相关信号通路，活化下游相关因子，提高患者机体免疫力。5)芪黄勇安汤能够激活相关的免疫机制，上调了IL-4和IL-6的表达，增强患者免疫力，体现了本方抗炎消肿，清热解毒等功效。关键词
2、：断肢(指)再植；芪黄勇安汤；血液流变；bFGF和VEGF；TLR4和TLR9；IL-4和IL-6作者：沈小芳指导教师：杨惠林课题来源：本课题为无锡市科技计划（医疗卫生）资助项目（CSEW1N1105）III英文摘要芪黄勇安汤对断肢(指)再植和组织移植术后造血功能及免疫功能影响的临床研究ClinicalStudyonhematopoieticfunctionandImmunologicalFunctionofbrokenlimb(finger)replantationandtissuetransplantationafteradministratio
3、nofQihuangYonganDecoctionAbstractAim:ResearchQihuangYongansouptopromotelimb(finger)replantationandtissuetransplantationpostoperativeneovascularization,toimprovethesignsofthepatientsaftersurgery,tooptimizevariousindicatorsofhemorheologyinpatients,toimprovebodyimmunityinpatients,
4、whichwouldprovideclinicalevidenceforitreasonableapplication.Methods:Atotalpatientsweredividedintotwogroups:controlgroup,thepostoperativeroutinetobeanti-infectiveandrehydrationtherapy,andoraladministrationof200mLcorrigentasplacebo.experimentalgroup,accordingtoprincipleofsyndrome
5、differentiationthepatientstookQihuangYonganDecoction(AnDecoctiongroupforshort),andafteroperationthepatientsstartingmedication1dosedaily×1week,whichtwiceoraladministrationafterdecoctedwithwater.Theserumwascollectedinthetimepointsofpostoperative6h,12h,48h,72hand120h.Thesymptomsan
6、dphysicalsignswererecorded,examplepain,bleeding,skincolor,skintemperatureandswellingandsoon;Detectionindexofhemorheologyincludingprothrombintimeandsoon;detectionofbFGFandVEGFinserumofpatientsbyflowcytometry;detectionofthemRNAlevelsofTLR4andTLR9inlymphocytewhichisolatedfromserum
7、ofpatients;detectionofconcentrationofimmunefactorsofIL4andIL6inserumofpatients.Result:1)Throughobservationanddetectionofthedifferentsignsofthetwogroupsateachtimepoint,wefindthatthepainhadbeenreducedsignificantly,especiallyafter48hinAnDecoctiongroup,andthepainwaslessobviousfrom1
8、20h.ThebleedingstatewasalsosignificantimprovementinAnD
