ccl18、mvd在乳腺癌组织中表达和其和患者预后关系探究

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1、CCL18.MVD在乳腺癌组织中表达和其和患者预后关系探究［摘要］目的研究趋化因子配体18(CCL18)与肿瘤微血管密度(MVD)在乳腺癌组织中表达水平及与患者预后的关系。方法收集2011年7月〜2012年12月我院乳腺外科病理确诊为乳腺癌患者癌组织标本90例，癌旁组织标本30例及乳腺良性病变组织30例。应用免疫组化法检测CCL18和MVD在3类组织中表达水平。结果CCL18在乳腺癌组织组的表达明显高于癌旁组织组和良性组织组(P=0.000),并且乳腺癌的分期越晚CCL18在乳腺癌组织组表达水平越高(P=0.000),乳腺癌组织组MVD的表达明显高于

2、其余两组(P=0.000),且表达水平在III期乳腺癌组织中明显高于I期和II期(P=0.000)。结论CCL18和MVD均可作为乳腺癌标志物之一，两者表达水平对于治疗和预后均有重要的意义。［关键词］乳腺癌；趋化因子18；肿瘤微血管密度；预后［中图分类号］R737.9［文献标识码］B［文章编号］1673-9701(2013)36-0020-03TheexpressionofCCL18andMVDinbreastcancerandtherelationshipbetweentheirexpressionlevelsandpatients，prognos

3、isHUZujianlXUHaibinlRENXingchang2HEJunlinglSUKunlunlYANGOuoulLUOHuaiLIUDianlei31.DepartmentofBreastOncology,HospitalofTraditionalChineseMedicineofHangzhouCityinZhejiangProvince,Hangzhou310007,China；2.DepartmentofPathology,HospitalofTraditionalChineseMedicineofHangzhouCityinZhej

4、iangProvince,Hangzhou310007,China；3.DepartmentofGeneralSurgery,HospitalofTraditionalChineseMedicineofHangzhouCityinZhejiangProvince,Hangzhou310007,China[Abstract]ObjectiveToinvestigatetheexpressionofCCL18(chemokineCC-motifligand18)andMVD(microvesseldensity)inbreastcancerandther

5、elationshipbetweentheirexpressionlevelsandpatients，prognosis・MethodsNinetycancertissuesamplesand30pericarcinomatissuesamplesfrompatientswithbreastcancer,and30tissuesamplesfrombenignbreastdiseasesdiagnosedinthedepartmentofpathologyinourhospitalwerecollectedfromJuly2011toDecember

6、2012.ImmimochemistrywasusedtodetecttheexpressionlevelsofCCL18andMVDinthetissuesamples・ResultsTheexpressionofCCL18wassignificantlyhigherincancertissuesamplesthanthoseinpericarcinomatissuesamplesandsamplesfrombenignbreastdiseases(P二0.000),andtheexpressionlevelofCCL18wasmuchhigher

7、inadvancedbreastcancer(P=0.000).TheexpressionofMVDwassignificantlyhigherincancertissuesamplesthanthoseinpericarcinomatissuesamplesandsamplesfrombenignbreastdiseases(P二0.000)，andtheexpressionlevelofMVDwasmuchhigherinphaseIIIbreastcancerthanthoseinphaseIandII(P=0.000).ConclusionC

8、CL18andMVDwerebothmarkersforbreastcancer.Theirexpressi