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1、中文摘要原发性失眠症患者认知功能与生活质量的研究害。(2)病程的长短,病情的严重程度以及伴发的焦虑抑郁情绪是导致认知功能损害的相关影响因素。(3)原发性失眠症患者的生活质量在生理、心理、独立性、社会关系、环境等维度和总体生活质量都有显著降低。(4)失眠所伴随的焦虑抑郁情绪,失眠的严重程度和有无家族史是影响原发性失眠症患者生活质量的主要因素。关键词:原发性失眠症;认知功能;神经心理学;生活质量作者:陈美玲指导老师:兰光华IIAstudyoncognitivefunctionandqualityoflifeinPIpatientsAbstractAstudyonc
2、ognitivefunctionandqualityoflifeinpatientswithprimaryinsomniaAbstractObjective:(1)Toexplorethecharacteristicsofcognitivefunctionimpairmentanditsinfluencingfactorsinthepatientswithprimaryinsomnia(PI),sowecanprovidetheneuropsychologicalbasisforthestudyofcognitivefunctionofPIpatients.(
3、2)Toexplorethequalityoflife(QOL)anditsinfluencingfactorsinpatientswithprimaryinsomnia,sowecanprovidescientificevidenceforimprovingthequalityoflifeofPIpatients.Methods:(1)NeuropsychologicaltestsincludingWechslermemoryscale(digitalaccumulation,visualrecall,visualreproduction,associati
4、velearning),digitspan,digitcancellation,trail-markingtest(TMT),Wisconsincardsortingtest(WCST)wereusedtoevaluatetheattention,memoryandexecutivefunctionin46PIpatients(PIgroup)and40healthycontrols(HCgroup);(2)TheWHOQOL-BREFwasusedtoassessedthequalityoflifein50PIpatientsand40healthycont
5、rols;(3)TheseverityofinsomniaanditsaccompanyinganxietyordepressionsymptomsinPIpatientswereseparatelyassessedbyPittsburghsleepqualityindex(PSQI),Self-ratinganxietysale(SAS)andSelf-ratingdepressionsale(SDS).Results:(1)ThecognitivefunctionanditsinfluencingfactorsinPIpatients:jComparedw
6、iththehealthycontrols,theachievementsofdigitaccumulation,visualrecall,visualreproduction,associativelearning,digitspanbackward,theerrorrateofdigitcancellationtest,trail-markingtestBandB-AandWisconsincardsortingtest(WCST)weresignificantlyworseinthePIpatientsexceptthecorrectresponseso
7、fWCST.kInthePIpatients,theSDSscorewaspositivelycorrelatedwithPSQIandSASscore;thedigitalaccumulationscorewasnegativelycorrelatedwiththecourse;theassociativelearningscorewasnegativelycorrelatedwithPSQI,thetimeoftrailmarkingtestBandB-AwerepositivelycorrelatedwiththecourseandtheRpe%ofWC
8、STwaspositivelycorr