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1、XX大学毕业论文原发性干燥综合症患者血清IL2014年6月25日原发性干燥综合症患者血清IL作者：袁双龙，蒋莉，张晓莉，李舒帆，段宏梅，王晓菲【关键词】原发性干燥综合症;，甲状腺功能减退症;白细胞介素SerumIL21levelinpatientswithprimarySjgren"ssyndromeandclinicalsignificanceofIL21[Abstract]AIM:ToinvestigatetherelationbetweenthechangeofsemmIL21levelandotherlaboratoryindex
2、esbydetectingserumIL21levelfrompatientswithprimarySjgren"ssyndrome(pSS)andexploretheroleofIL21inpSS.METHODS:ThelevelofserumIL21from40pSSpatientsdiagnosedaccordingto2002revisedinternationalclassificationcriteriaforpSSand30healthypersonsweredetectedbyenzymelinkedimmunosorbe
3、ntassay(ELISA)respectively.Meanwhile,FT3，FT4,TSH,TgAb,TPOAbweredetectedbyImmunochemiluminescenttechnique.Doublediffusionmethod,WestergrenandautomaticgelmethoddetectedantSSAandantSSBantibody,ESRandserumproteinelectrophoresisrespectively.TherelationshipbetweenserumIL21level
4、andotherclinicalsymptomofthepatientswasanalyzed.RESULTS:ThelevelofserumIL21inpatientswithpSS(1051±335)ng/Lwasobviouslyhigherthanthatinhealthycontrol(466±90ng/L),(P0.05).ThelevelsofserumIL21intheselfantibodypositivegroup,parotidglandswellingpaingroup,rashgroupandincorporat
5、inghypothyroidismgroupwerehigherthanthoseintheirnegativecontrolgroups,andthereweresignificantdifferences(P0.05).Inaddition,ThelevelofserumIL21levelinpSSpatientsshowedpositivecorrelationwithyglobulin(r=0.719,P0.05)andESRlevel(r=0.745,P0.05).CONCLUSION:Theevidentincreaseofs
6、erumIL21levelinpSSpatientshaspositivecorrelationwiththelevelsofyglobulinandESR,whichsuggeststhatIL21mayplayacriticalroleinthepathogenesisofpSS・[Keywords]primarySjgren"ssyndrome;hypothyroidism;interleukin21(IL21)［摘要］目的：通过检测原发性干燥综合症(pSS)患者血清白细胞介素21(IL21)的表达水平，探讨其水平变化与pSS患者其
7、他实验室检测指标关系以及其在pSS发病中的作用。方法：选取符合2002年修订的pSS国际分类标准的40例初诊pSS患者。采用双抗体夹心ELISA方法检测该组患者及30例正常对照者血清中IL21的水平。同吋，采用免疫化学发光法检测患者的甲状腺情况包括FT3、FT4、TSH、TgAb、TPOAbo抗SSA和抗SSB抗体、ESR、血清蛋白电泳检测分别采用免疫双扩散法、魏氏法、全自凝胶法。并与患者的其他临床表现进行统计学分析。结果:pSS患者血清IL21水平为(105H335)ng/L,明显高于正常对照组水平［(466±90)ng/L,P005］
8、。特别是pSS患者中抗体阳性组、有腮腺肿痛组、皮疹组、合并甲状腺功能减退组血清IL21水平均高于各自阴性对照组，差异具有统计学意义(P005)o而且pSS患者中IL21水平与丫球蛋白及血沉存在
