拉莫三嗪治疗脑损伤后脑水肿的实验研究

《拉莫三嗪治疗脑损伤后脑水肿的实验研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、拉莫三嗪治疗脑损伤后脑水肿的实验研究LamotrigineisanexperimentalstudyofcerebraledemaafterbraininjuryUpdatedate:2010-09-08chengyuanChencomplex,zhangxiaoping【abstract】objectivetobydefenseratsmodel,toobservethebraininjuryaftertheexcitatoryaminoacidglutamicacidandlamotriginetreatmenteffectofacutebrainedema,andtoexploreit

2、sactionmechanism.Methodsusingdry-wetweightmethod,andaminoacidanalysisandmicrodialysistechnologydifferentareasafterbraininjury,notatthesametimeinthewatercontentofbraintissueandtheconcentrationofglutamate・Results(1)theamountofwaterinthebraintissueofthebraininjurygroupwassignificantlyhigherthanthatint

3、hecontrolgroup.(2)brainedemaandextracellularglutamateinthelesionofthebrainlesionwereself-expanding;(3)theamountofwaterinthebraintissueoflamotrigineandtheconcentrationofglutamatewassignificantlylowerthanthatofthenon-treatmentgroup・Conclusionlamotriazineplaysatherapeuticroleincerebraledemabyinhibitin

4、gthereleaseofglutamatefromnervecells・【keywords】thecerebraledemaofcerebraledemaofcerebraledema,lamotriazineEffectofLamotrigineontheFollowingTraumaticBrainInjuryinRatsCHENGYuan,CHENfu-ren,WUYong,etalDept.OfNeurosurgery,SecondAffiliatedHospital,ChongqingMedicalUniversity,Chongqing400042[Abstract]AimTo

5、investigatetheeffectoflamotrigine(LTG)oncerebraledemafollowingtraumaticbraininjury,andtodiscussthemechanism・MethodsThisstudywasdoneontheexperimentalanimalmodels(rats)withimpactedbraininjury.Thechangeofwatercontentinbrainwasmeasuredwithudrying-wetvmethod,andthechangeofglutamatewasmeasuredwithmicrodi

6、alysistechniqueandaminoacidsautomaticanalyzes.Results(1)Thewatercontentandglutamateintheinjuredbrainweresignificantlygreaterthanthoseinthecontrolgroup・(2)Intheinjuredbrain,thecontentsofwaterandglutamateshowedaself-diffusionprocess・(3)ThecontentsofwaterandglutamateintheLTG-treatedgroupweresignifican

7、tlylowerthanthoseinthenontreatedgroup・ConclusionLTGcandealwithcerebraledemabyinhibitingneuronstoreleaseglutamate・(Keywords)BraininjuryisthesameastheaminoacidsLamotrigineOutsideofbackinjuryofbraintissuefluid