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1、双重阻断RASS对2型糖尿病肾病血管生长调控因子表达的影响1△1※21秦会娟,温玉洁,刘陶文，阳晶晶12（广西壮族自治区南溪山医院暨桂林医学院附属南溪山医院内分泌科,肿瘤科,广西桂林541002）摘要：目的探讨双重阻断肾素-血管紧张素-醛固酮系统（renin-angiontensinⅡ-aldosteronesystem，RASS）对2型糖尿病肾病血管生长调控因子表达的影响。方法将糖尿病肾病（DN）患者60例，随机分为3组，实验组A.贝那普利组10mg/日B.厄贝沙坦组150mg/日C.贝那普利组10mg/日、厄
2、贝沙坦150mg/d联合应用组各20例。用药前、后（两个月）各留取空腹血5ml用来检测血清VEGF和ENS。并对用药前后的尿微量白蛋白排泄率（UAER）作一比较。D组：空白对照组为同一时间段在我院体检中心体检的人员20例，不加任何干预。结果实验组VEGF、ENS水平均较对照组升高P<0.01；药物干预后，3组UAER、VEGF、ENS水平均有下降，联合用药组下降更明显P<0.05。结论研究证实VEGF和ENS平衡的紊乱在DN的发生发展过程中起重要作用，双重阻断RAS可明显减少尿蛋白，延缓肾脏病变。关键词：双重阻断
3、；RASS；糖尿病肾病；VEGF；ENS.中图分类号：R587.2文献标志号：A文章编号：DaubleblockadeofRASSontype2diabeticnephropathyvasculargrowthregulatorymoleculesexpressioninfluence112QINHui-juan,WENYu-jie,LIUTao-wen.(1.DepartmentofEndocrinology,GuilinMedicalUniversityNanxishanHospitalofGuangxiZh
4、uangAutonomousRegion,Guilin541002,China;2.DepartmentofOncology,GuilinMedicalUniversityNanxishanHospital,GuangxiZhuangAutonomousRegion,Guilin541002,China)Abstract:ObjectiveToinvestigatethedualblockadeoftherenin-angiotensin-aldosteronesystem(renin-angiontensinI
5、I-aldosteronesystem,RASS)ontype2diabeticnephropathyvasculargrowthregulatorymoleculesexpressioninfluence.Methodsdiabeticnephropathy(DN)in60patients,wererandomlydividedinto3groups,theexperimentalgroupAbenazeprilgroup10mg/dB.Irbesartangroup150mg/dCbenazeprilgrou
6、p10mg/D,150mg/Dirbesartancombinedwith20casesineachgroup.Beforetreatment,later(twomonths)alltakethefastingblood5mlusedtodetectserumVEGFandENS.Theanalysesofurinealbuminexcretionrate(UAER)tomakeacomparison.GroupD:blankcontrolgroupforthesametimeperiodinourhospita
7、lphysicalexaminationcenterofthemedicalstaffin20cases,withoutanyintervention.ResultstheVEGF,ENSlevelsthanthoseinthecontrolgroupP<0.01;drugintervention,3groupsofUAER,VEGF,ENSlevelsdrop,thecombinationgroupdecreasedmoreobviouslyP<0.05.Conclusionthestudyconfirmedt
8、hatVEGFandENSbalancedisordersintheoccurrenceanddevelopmentofDNplaysanimportantroleintheprocessofdualblockade,RAScouldsignificantlyreduceurinaryprotein,slowtheprogressionofrenallesions.Key
