干扰素治疗对慢性乙肝患者cd4

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1、干扰素治疗对慢性乙肝患者CD4+CD25+调节性T细胞水平的影响研究［摘要］目的探讨慢性乙型肝炎患者在干扰素抗病毒治疗中外周血调节性T细胞的变化及临床意义。方法选择2013年1月〜2015年1月在我院行干扰素抗病毒治疗的慢性乙肝患者60例及同时期体检的健康成人20例，分别于治疗前、治疗后第12、24、36、48周及停药后24周收集患者的外周血，比较外周血中CD4+CD25+调节性T细胞(Tregs)>血清HBV-DNA载量以及谷氨酸-丙酮酸转氨酶(ALT)的变化。结果治疗前，完全应答组、部分应答组以及无应答组外周血CD4+CD254-调节性T细胞比例、ALT含

2、量以及HBV-DNA载量组间比较差异无统计学意义(P>0.05),但均显著高于健康对照组，差异有统计学意义(P<0.05)；治疗后，完全应答组和部分应答组患者各时间段Tregs比例均较治疗前显著下降(P〈0.05)；在治疗及停药期间,完全应答组和部分应答组患者的Tregs比例一直在下降;治疗期间HBV-DNA转阴患者的Tregs比例逐步下降且显著低于未转阴的患者(P<0.05)；治疗期间血清学转换的患者Tregs比例逐步下降且显著低于未转换的患者(P<0.05)o结论慢性乙肝患者在接受干扰素抗病毒治疗期间及治疗后，其外周血调节性T细胞比例下降，且越早出现下降的

3、患者其治疗后血清转阴的可能性越大。［关键词］乙型肝炎；干扰素；调节性T细胞;外周血［中图分类号］R512.62［文献标识码］A［文章编号］1673-9701(2016)24-0012-04EffectofCD4+CD25+regulatoryTcelllevelofchronichepatitisBduringinterferontherapingXUEHaibolMAL订i2LINXianfanlWUJinmingl1.TheFirstDepartmentofGastroenterology,theFirstAffiliatedHospitalofWenzh

4、ouMedicalUniversity,Wenzhou325000,China；2.DepartmentofRheumatologyandImmunology,theFirstAffiliatedHospitalofWenzhouMedicalUniversity,Wenzhou325000,China[Abstract]ObjectiveToinvestigatethechangesandclinicalsignificanceofperipheralbloodregulatoryTcellsinchronichepatitisBpatientstreate

5、dwithinterferon.Methods60patientswithchronichepatitisBwhoweretreatedwithinterferonand20healthyadultswereselectedfromJanuary2013toJanuary2015inourhospital.Peripheralbloodwascollectedbeforetreatmentand12thweeks,24thweeks,36thweeks,48thweeksaftertreatmentand24weeksafterwithdrawal,thech

6、angesofCD4+CD25+regulatoryTcells(Tregs),serumHBV-DNAandglutamatepyruvateaminotransferase（ALT）inperipheralbloodwerecompared・ResultsTherewerenosignificantdifferencesintheproportionofCD4+CD25+regulatoryTcells,ALTcontentandHBV-DNAcontentbetweencompleteresponsegroup,partialresponsegroupa

7、ndnonresponsegroupbeforetreatment（P〉0.05）,buttheyweresignificantlyhigherthanthoseinhealthycontrolgroup,therewerestatisticallysignificantdifferencesbetweenthegroups（P〈0・05）；TheproportionofTregsinthecompleteresponsegroupandthepartialresponsegroupaftertreatmentweresignificantlydecrease

8、dcomparedwiththatbe