资源描述：
《brms1-hdac1-vegf-c在乳腺癌组织中的表达及意义》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、BRMS1HDAC1VEGF-C在乳腺癌组织中的表达及意义［摘耍］冃的探讨BRMS1.HDAC1及VEGF-C蛋白在乳腺癌、乳房纤维瘤及正常乳腺组织的表达及意义。方法采用免疫组织化学方法随机检测60例乳腺癌组织标木BRMSkHDAC1、VEGF-C蛋口的表达,随机收集乳房纤维瘤组织及其旁正常乳腺组织各20例作为对照组，结合临床病理资料分析其临床意义。结果BRMS1在乳腺癌组织小表达率为60%,在乳房纤维瘤组织中表达率为85%,在正常乳腺组织中表达率为95%,乳腺癌组织中的BRMS1的表达明显低于乳房纤维瘤和正常乳腺组织(P〈0.05)。11
2、DAC1在乳腺癌组织屮表达率为91.7%,在乳房纤维瘤组织屮表达率为55%,在正常乳腺纽•织屮表达45%,HDAC1在乳腺癌纟R织屮的表达明显高于乳房纤维瘤和正常乳腺组织(P〈0.01),乳腺癌中VEGF-C的表达58.3%高于乳房纤维瘤25%和正常组织20%(P<0.05)o结论BRMS1、HDAC1和VEGF-C共同参与了乳腺癌的转移，联合检测BRMS1.IIDAC1及VEGF-C的表达有助于判断其预后。［关键词］BRMS1;HDAC1;VEGF-C;乳腺癌;免疫组织化学［中图分类号］R737.9［文献标识码］A［文章编号］1673-970
3、1(2010)09-10-03ExpressionandSignificanceofBRMS1,HDAC1andVEGF-CinBreastCancerXIAGenyuCHENBinYijishanHospitalofWannanMedicalCollege,Wuhu241001,China［Abstract］ObjectiveToinvestigatetheexpressionandclinicalsignificsnceofbreastcancermetastasissuppressor1(BRMS1)protein,histonedeac
4、etylase1(HDAC1)andvascularendothelialcellgrowthfactor-C(VEGF-C)proteininbreastcancer.MethodsTheexpressionofBRMS1protein,HDAC1andVEGF-Cwasdetectedbyusingimmunohistochemicaltechniquein60casesofbreastcancer,20casesofbreastfibroidsand20casesofadjacentnormalbreasttissueascontrola
5、ndtheclinicalsignificancewasanalyzedwithhistopalthologicalrecords.ResultsThepositiverateofBRMS1expressionwas60%inbreastcancertissue,85%inbreastfibroidsand95%innormalbreasttissue,showingthepositiverateofBRMS1inbreastcancerwasmuch1owerthanthatinbreastfibroidsandnormalbreasttis
6、sue(P<0.05).ThepositiverateofHDAC1expressionwas91.7%inbreastcancer,55%breastfibroidsand45%innormalbreasttissue,showingthepositiverateofHDAC1inbreastcancerwasobviouslyhigherthanthatinbreastfibroidsandnormalbreasttissue(P〈0.01).ThepositiverateofVEGF-Cexpressionwas58.3%inbreast
7、cancer,25%inbreastfibroidsand20%innormaIbreasttissue(P<0.05).Cone1usionBRMS1,HDAC1andVEGF-Cmightsynergisticallypromotethemetastasisofbreastcancer.Therefore,thecombineddetectionoftheexpressionofBRMS1HDAC1andVEGF~Cmaybehelpfulinthedeterminationoftheprognosisofbreastcancer.［Key
8、words］BRMS1;HDAC1;VEGF-C;Breastcancer;Immunohistochemistry肿瘤转移抑制基因(BRMS1)是抑
