txnip及trxr1蛋白在乳腺癌组织中的表达及意义

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1、授予单位代码10089学号或申请号13057HebeiMedicalUniversity硕士学位论文在职科学学位TXNIP及TrxRl蛋白在乳腺癌组织中的表达及意义学位申请人：李晓敏导师：史永红教授专业：病理学与病理生理学二级学院：基础医学院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师(或指导小组)的指导下，由本人独立完成。本学位论文研究所获得的研究成果,其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文,第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识产权

2、均归河北医科大学所有。否则,承担相应法律责任。研究生签名;^导师签章一级学院领导盖章：河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果,除了文中特别加以标注和致谢等内容外,文中不包含其他人已经发表或撰写的研究成果,指导教师对此进行了审定。本论文由本人独立撰写,文责自负。目录中文摘要·············································································1英文摘要·············································

3、································4英文缩写·············································································8研究论文TXNIP及TrxR1蛋白在乳腺浸润性导管癌中的表达及意义前言·············································································9资料与方法······················································

4、··············10结果·············································································12附图·············································································15附表·············································································20讨论··························

5、···················································23结论·············································································25参考文献·······································································26综述乳腺癌治疗靶点的研究进展············································29致谢··············

6、·····································································42个人简历·············································································43中文摘要TXNIP及TrxR1蛋白在乳腺浸润性导管癌中的表达及意义摘要目的：乳腺癌(breastcancer)是女性最常见的恶性肿瘤之一，发病率占全身各种恶性肿瘤的7-10%。近年来，乳腺癌已成为严重危害妇女身心健康及生命的重要的恶性肿瘤之一。因此，探讨与乳腺癌有关

7、的因素，寻找预防和治疗的有效方法，对判断预后、指导治疗、提高生活质量具有十分重要的意义。硫氧还蛋白相互作用蛋白（thioredoxin-interactingprotein,TXNIP）是一种氧化还原调节蛋白，它能够与硫氧还蛋白(thioredoxin,Trx)的活性半胱氨酸残端结合，从而抑制其清除活性氧的功能功能。大量的研究已证实，TXNIP基因与多种恶性肿瘤的有关，是判断肿瘤预后的重要指标。硫氧还蛋白还原酶1（thioredoxinreductase1，TrxR1）是存在于哺乳动物细胞内的一种调节细胞氧化还原状态的酶类，其重要功能是使细胞保持硫氧