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ID:29049312
大小:9.07 MB
页数:81页
时间:2018-12-16
《《淋巴瘤病人》word版》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、青岛大学硕士学位论文淋巴瘤病人MMP--2和TIMP--2的表达及其临床意义姓名:许宏申请学位级别:硕士专业:内科学(血液病)指导教师:赵洪国20110603淋巴瘤病人MMP-2和Tl_P-2的表达及其临床意义摘要目的探讨淋巴瘤病人血清基质金属蛋白酶-2(MMP一2)和组织金属蛋白酶抑制因子一2(TIMP一2)的表达及其临床意义。方法应用酶联免疫吸附法检测32例非霍奇金淋巴瘤(NHL)病人和8例霍奇金淋巴瘤(HL)病人的血清删P一2及TIMP-2水平,计算M/T(埘P_2/TIMP-2)值,并动态观察lO例初诊非霍奇金淋巴瘤(NHL)病人治疗半年
2、后的MMP一2及TIMP一2水平变化。.结果淋巴瘤病人血清M船一2、TIMP-2水平及M/T(删P-2/TIMP-2)值均明显高于正常对照组(P<0.05)。NHL病人血清MMP-2水平及M/T值与其病理类型、临床分期和骨髓侵犯等显著相关(PO.05);初治、复发、难治NHL病人的血清删P一2水平、TIMP一2水平和M/T}=L值均无明
3、显差别(P>0.05)。HL病人血清删P-2水平及U/T值仅与其病理类型有关(P4、fserumMMP一2andTIMP-2levelsinpatientswithlymphomaAbstractObjectiveTostudytheserumlevelandrelationshipofMMP·-2andTIMP·-2inpatients、Ⅳimlymphomaanditsclinicalsignificance.MethodsContentsofserumMMP-2‘andTINIP-2in32patientswithnon-Hodgldn’Slymphomaand8patientswithHodgkin’Slymphomaw5、eredeterminedbyusingenzymelinkedimmunosorbentassay(ELISA),M/T(MMP·2/TIMP一2)ratioWascounted,and10newlydiagnosedpatientswimnon—Hodgkin’slymphomawel"efollowed6monthsaftertreatment.ResultsContentsofserumMMP-2andTIMP-2andM/T(MMP一2/TIMP-2)ratioinlymphomapatientswel"esignificantlyin6、ereasedcomparedwithnormalcontrol(P<0.05).ThereWaspositivestatisticalcorrelationbetweenthelevelofSeI'BmMMP一2andM/Tratioandthepathologicaltype,clinicalstage,andbonemarrowinfiltrationinnon-Hodgkin’Slymphomapatiems,thehigherlevelofMMP-2andM/Tratio,thepoorerprognosis.Thelevelofser7、umMMP-2andM/Tratiointhecompleteremission(CR)subjectsofnon-Hodgkin’Slymphomapatientsweresignificantlylowerthanthatinuntreatedandrelapsed/refractorypatients(P<0.05),butnotdifferenttoTIMP一2(P>0.05).TherewerenodifferenceinMMP一2andTIMP一2andM/Tratiobetweenpatientsnewlydiagnosedandr8、elapsed/refractory.AsforHL,thelevelofserumMMP一2andM/Tratioonlycorrel
4、fserumMMP一2andTIMP-2levelsinpatientswithlymphomaAbstractObjectiveTostudytheserumlevelandrelationshipofMMP·-2andTIMP·-2inpatients、Ⅳimlymphomaanditsclinicalsignificance.MethodsContentsofserumMMP-2‘andTINIP-2in32patientswithnon-Hodgldn’Slymphomaand8patientswithHodgkin’Slymphomaw
5、eredeterminedbyusingenzymelinkedimmunosorbentassay(ELISA),M/T(MMP·2/TIMP一2)ratioWascounted,and10newlydiagnosedpatientswimnon—Hodgkin’slymphomawel"efollowed6monthsaftertreatment.ResultsContentsofserumMMP-2andTIMP-2andM/T(MMP一2/TIMP-2)ratioinlymphomapatientswel"esignificantlyin
6、ereasedcomparedwithnormalcontrol(P<0.05).ThereWaspositivestatisticalcorrelationbetweenthelevelofSeI'BmMMP一2andM/Tratioandthepathologicaltype,clinicalstage,andbonemarrowinfiltrationinnon-Hodgkin’Slymphomapatiems,thehigherlevelofMMP-2andM/Tratio,thepoorerprognosis.Thelevelofser
7、umMMP-2andM/Tratiointhecompleteremission(CR)subjectsofnon-Hodgkin’Slymphomapatientsweresignificantlylowerthanthatinuntreatedandrelapsed/refractorypatients(P<0.05),butnotdifferenttoTIMP一2(P>0.05).TherewerenodifferenceinMMP一2andTIMP一2andM/Tratiobetweenpatientsnewlydiagnosedandr
8、elapsed/refractory.AsforHL,thelevelofserumMMP一2andM/Tratioonlycorrel
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