异常黑胆质病患者血栓因子cd41 cd62p及fib改变的研究

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1、新疆医科大学硕士学位论文异常黑胆质病患者血栓因子CD41、CD62p及FIB改变的研究姓名：曹晓滨申请学位级别：硕士专业：中西医结合临床指导教师：哈木拉提·吾甫尔201109新疆医科大学医学硕士论文异常黑胆质病证患者血栓因子CD41、CD62p及FIB改变的研究研究生：曹晓滨导师：哈木拉提·吾甫尔教授摘要目的：评估和分析不同年龄异常黑胆质病证患者与血小板活化分子0【．颗粒膜蛋白(CD62p)、整合素基因家族IIb／IIIa整合素(CD41)、纤维蛋白原(FIB)的关系。方法：采用单克隆抗体和流式细胞仪技术，研究分析不同年龄组(老年组年龄≥60岁

2、、中年组年龄45"--'59岁、青年组年龄<45岁)异常黑胆质病证患者的血小板活化分子CD41、CD62p及FIB的表达及相关性。结果：老年异常黑胆质病证组患者的CD62p及FIB显著高于其他不同年龄组异常黑胆质病证患者(P0．05)。结论：①异常黑胆质病证患者老年人居多。②随着年龄的增长异常黑胆质病证患者的血小板活化分子CD62p及FIB明显增加，患者血小板黏附蛋白CD62p表达和释放增加，处于激活状态。③就老年组的异常

3、黑胆质病证患者而言，更应关注多种血小板活化因子的刺激使体内血小板活化，更要预警、预测、预防老年患者异常黑胆质证的发生和血栓形成。关键词：异常黑胆质证；不同年龄组；血小板活化分子；血栓形成新疆医科大学医学硕士论文TheAbnormalSavdaSyndromeCD41，CD62pandFibrinogenChangeofResearchPostgraduate：CaoxiaobinTutorpro：ProfessorWUPAbstractObjective：Assessmentandanalysisofdifferentageexceptiona

4、bnormalsavdasyndrometopatientswithPlateletActivationmoleculara-particlesmembraneprotein(CD62p)，IntegringenefamilyIIb／IllaIntegrin(CD41)，Fibrinogenrelationship．Methods：Useofmonoclonalantibodiesandflowcytometrytechnology,researchandanalysisofdifferentagegroups(elderlyaged>f60y

5、ear-old，middleagegroupsage45"-,59year-oldagegroup，youth<45岁)withtheexceptionofabnormalsavdasyndromeofplateletactivatingmoleculesCD41，CD62pandFIBexpressionandcorrelation．Results：AbnormalsavdasyndromeofelderlygrouppatientswithCD62p，CD41andfibrinogenweresignificantlyhigherthano

6、theragegroupsabnormalsavdasyndromepatients(P<0．01)；AbnormalsavdasyndromedifferentagegroupsofpatientsCD41，CD62pandfibrinogenwerehigherthanotheragegroupsAbnormalsavdasyndromeCD41，CD62pandfibrinogen(P<0．05)．Theincreaselevelofgrowthandagesignifcantlycorrelated(P<0．01)．Conclusion

7、：OTheoldagepatientswithabnormalsavdasyndromewasinthemajority．②WithageinpatientswithAbnormalSavdaSyndromeinplateletactivatingCD62pandFIBsignificantlyincreased，plateletadhesionproteinCD62pexpressionandreleaseincreased，inastateofactivation．③Theelderlyage-grouppatientsofabnormal

8、savdasyndrome，moreattentionshouldbeconcernedaboutavarietyofplateletactivati