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1、龙血竭对急性心肌梗死家兔左心功能的保护研究【摘要】目的探?龙血竭对急性心肌梗死家兔左心功能的保护作用。方法将30只家兔随机分为三组，假手术组、心肌梗死组、龙血竭干预组，每组10只。采用左冠状动脉前降支结扎法，建立急性心肌梗死模型。观察HE染色的心肌组织结构变化，测量心率、左心室收缩末压(LVSP).左心室舒张末压(LVEDP)、左心室内压最大上升速率(+dp/dtmax)、左心室内压最大下降速率(-dp/dtmax)0结果龙血竭干预组心肌组织结构明显好于心肌梗死组；心肌梗死组和龙血竭干预组其心率较假手术组明显减慢，龙血竭干预组心率减慢更明显(P<0.05或0.0
2、1)。心肌梗死组、龙血竭干预组与假手术组比较，其LVSP均明显下降、LVEDP均明显升高，而心肌梗死组与龙血竭干预组比较，其LVSP下降更明显、LVEDP升高更明显(P〈0.05或0.01)。心肌梗死组和龙血竭干预组其+dp/dtmax和-dp/dtmax均较假手术组明显下降，且心肌梗死组较龙血竭干预组下降更明显，差异有统计学意义(P〈0.01)。结论龙血竭对急性心肌梗死家兔左心功能具有较好的保护作用。【关键词】龙血竭；急性心肌梗死；左心功能；保护中图分类号：R542.2+2文献标识码：ADOI:10.3969/j.issn.10031383.2017.01.0
3、04AstudyonprotectioneffectofRcsinaDraconisonleftventricularfunctionofacutemyocardialinfarctionrabbitsCHENGChuyongl,LIANGLimei2,LIUYan3,LIZhile3,LIKela3,LIUWenjingl,ZHANGZhuohual,HUANGZhaohe3A(1.GraduateSchool,2.DepartmentofLaboratoryMedicineofAffiliatedHospital,3.DepartmentofCardiolo
4、gyofAffiliatedHospital,YoujiangMedicalUniversityforNationalities,Raise533000,China)[HJ1*2][HJ][Abstract]ObjectiveTostudyprotectioneffectofResinaDraconisonleftventricularfunctionofacutemyocardialinfarctionrabbits・Methods30rabbitswererandomlydividedintoshamoperationgroup,myocardialinfa
5、rctiongroupandResinaDraconisinterventiongroupwith10rabbitsineachgroup・Acutemyocardialinfarctionmodelwasestablishedbyleftanteriordescendingcoronaryarteryligationmethod.ThechangesofmyocardialtissuestructurewereobservedbyHEstaining,andheartrate,leftventricularendsystolicpressure(LVSP),l
6、eftventricularenddiastolicpressure(LVEDP),maximumriserateofleftventricularpressure(+dp/dtmax)andmaximumdescendingrateofleftventricularpressure(-dp/dtmax)weremeasured・ResultsThestructureofmyocardiumintheResinaDraconisintervontiongroupwassignificantlybetterthanthatinthemyocardialinfarc
7、tiongroup.HeartratesofmyocardialinfarctiongroupandResinaDraconisinterventiongroupsignificantlysloweddowncomparedwiththatoftheshamoperationgroup,andthatoftheResinaDraconisinterventiongroupdecreasedmoresignificantly(P表1三组家兔心率、LVSP、LVEDP、+dp/dtmax>-dp/dtmax(n=10,±s)分组心率(次/分)LVSP(mmHg)LV
8、EDP(mmHg)+dp
