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ID:28336997
大小:8.12 MB
页数:44页
时间:2018-12-09
《ctz癫痫模型与ptz ka模型的比较分析》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、优秀毕业论文复旦大学硕士学位论文AbstraCtEPilePsy15afrequentlyoeeurredCNSdisease,bynowmostseizureseanbeeontrolledbytreatment.However,weareshortofcomPletelyeffectivetheraPymethodsineontrollingePilePsybutsometimesuseAEDstosuPPresstheseizures.Atthesametime,wehaveknownlittleabou
2、tthemeehanismorPathogenesisofePilePtogenesis,andit15ve叮imPortanttofindouttheereationanddeveloPmentofseizures.SettinguPfastandhigh一effeetiveePilePsymodelseanProvideusbothwaystostudythemeehanismandnewtargetsforAEDssereening.InPresentstudywestudiedanewseizuremo
3、del(indueedbyCTZ)reeentlydeveloPedinourlab,alongwithseveralotherehemieally一indueedaeuteseizuremodelsinrathiPPocamPusinvivo.w亡analysesedandeomParedeharaetersofthesemodelsbyfieldpotential,behavioralandPharmaeologiealteehniques.Inthesemodelswefurtherstudiedsome
4、anti一ePilePtiedrugs’effeet,whiehmightProvidenewtargetsforfutureAEDsstudies.W匕foundthati.e.v.administrationofCTZ(5林mol,5林l)indueedrobustePilePtiformaetivitiesinatime一dePendentmannerstePPingfrommildsPontaneoussPikestohighlysynehronizedePilePtiformbursts.Italso
5、indueedinereasingnumbersofevokedPoPulationsPikefromsinglePeaktomultiPlePeaks.SubeutaneousadministrationofPTZ(383mg/kg)sharedasimilarProgressasCTZexeePtforsomediffereneesinintensityandtimeeourse.KAinducedamuehseverermodelthanCTZdidwhengive1.e.v.withafasterPro
6、gressandhigherintensity.BesidessPontaneoussPikesandbursts,KAalsoindueedrobustePilePtiformaetivitiesofaseizurestateeontaininglong一lastingeontinuouslyfiringsPikesasaeutestatusePilePtieus(ASE).TheseizuresensitivityrankingfromhightolowseemedasKA,PTZandCTZ.Neithe
7、raeutebehavioralnoreleetroPhysiologiealePilePtiformaetivitiesweregeneratedwhenPTZwasgiveni.e.v.atarelativelyhighdose.PharmaeologiealstudyshowedthatCTZandPTZmodel15differentinmeehanism.AdministrationofAlprazolam(o.4mg/kg,i.p.),ahigh一PoteneybenzodiazePine,effe
8、etivelyinhibitedbothCTZandPTZindueedbursts,buthaslimiteffeetonKAindueedASEstate.Whilenon一eolnPetitiveAMPAreeePtorantagonistGYKI53784(smg/kg,i.v.)onlysuPPressedCTZbutnotPTZinducedburstaetivities.
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