反复呼吸道感染儿童匹多莫德与维生素d治疗的临床疗效观察

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1、反复呼吸道感染儿童匹多莫德与维生素D治疗的临床疗效观察【摘要】目的分析研宄反令秃粑令道感染儿童联合匹多莫德和维生素D治疗的疗效和对机体免疫功能的影响。方法100例RRI儿童为研宄对象，采用随机法分为对照组和观察组，各50例。对照组患儿采用常规治疗，观察组患儿在对照组基础上加用匹多莫德和维生素D治疗，随访6个月。对比两组临床疗效、临床症状消退时间、T细胞亚群和免疫球蛋白的变化，随访期间统计复发次数。结果观组患儿总有效率显著高于对照组，差异有统计学意义。观察组患儿随访期间复发次数为次，对照组患儿为次，观察组患儿随访期间复发次数明显少于对照组。观察组发热消退时间、扁桃体肿大消退时间、肺部命分音

2、消退时间、咳嗽缓解时间均短于对照组，差异具有统计学意义；观察组治疗后T细胞亚群、免疫球蛋白A、免疫球蛋白G、免疫球蛋白M均高于对照组，差异具有统计学意义；对照组治疗前后T细胞亚群、免疫球蛋白比较差异无统计学意义。结论RRI儿童给予匹多莫德和维生素D联合治疗具有较好的疗效，可有效缓解临床症状，降低疾病的复发次数，同时还显著增强患儿的细胞免疫和体液免疫功能。【关键词】反复呼吸道感染；小儿；免疫调节剂；T细胞亚群；免疫球蛋白DOI：10.14163/j.cnki.ll-5547/r.2017.15.006Observationofclinicaleffectbypidotimodandvita

3、minDinthetreatmentofrecurrentrespiratorytractinfectionchildrenHUANGMing-jian.GuangzhouCityHaizhuDistrictMaternalandChildHealthCareHospital,Guangzhou510240,China【Abstract】ObjectiveToanalyzeandresearchcurativeeffectbypidotimodcombinedwithvitaminDinthetreatmentofrecurrentrespiratorytractinfectionchi

4、ldren，anditsinfluenceonimmunefunction.MethodsAtotalof100RRIchildrenasstudysubjectswererandomlydividedintocontrolgroupandobservationgroup，with50casesineachgroup.Thecontrolgroupreceivedconventionaltherapy，andtheobservationgroupreceivedadditionalpidotimodandvitaminDtotreatmentinthecontrolgroup.Theya

5、llreceivedfollow-upfor6months.Comparisonwasmadeonclinicaleffect，disappearancetimeofclinicalsymptoms,changesinTlymphocytesubsetandimmunoglobulin.Recurrentfrequencyinthetwogroupswassummarizedduringfollow-up.ResultsTheobservationgrouphadobviouslyhighertotaleffectiveratethanthecontrolgroup，andthediff

6、erencehadstatisticalsignificance.Theobservationgrouphadrecurrentfrequencyinfollow-upastimes，whichwastimesinthecontrolgroup，andtheobservationgrouphadobviouslylessrecurrenttimesthanthecontrolgroup.Theobservationgrouphadallshorterfeverremissiontime，antiadoncusremissiontime，lungraleremissiontime，andc

7、oughremissiontimethanthecontrolgroup,thetheirdifferencehadstatisticalsignificance.TheobservationgrouphadallhigherTlymphocytesubset，immunoglobulinA，immunoglobulinG，andimmunoglobulinMthanthecontrolgroup，andtheirdifferenc