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1、枸地氯雷他定与自血疗法联合治疗自身免疫性荨麻疹的疗效观察【摘要】目的，察枸地氯雷他定与自血疗法联合治疗自身免疫性荨麻疹的临床疗效。方法选取218例自体血清皮肤试验阳性的慢性荨麻疹患者为研宂对象，随机分成对照组、观察1组和观察2组，对照组口服枸地氯雷他定片治疗，观察1组给予自血疗法，即抽取患者自身静脉血肌注，1次/周，观察2组在自血疗法的同时门服枸地氯雷他定片治抒，三组患者均治疗8周；记录治疗前后瘙痒程度、风团数量等（UAS评定、4级评定法）变化情况，对比分析三组患者的疗效。结果治疗8周后，对照组总有效率为74.29%，观察1组总有效率为8
2、3.33%,观察2组总冇效率为92.11%,两个观察组的临床症状改善效果均明显优于对照组，差异宥统计学意义（P〈0.05）,观察2组与对照组间疗效比较差异有统计学意义（P〈0.01）。结论自身免疫性荨麻疹采用枸地氯雷他定与自血疗法联合治疗，能显著改善患者的临床症状。【关键词】慢性荨麻疹；自体血清皮肤试验；枸地氯雷他定；自血疗中图分类号：R758.24文献标识码：ADOI:10.3969/j.issn.10031383.2017.01.021Anefficacyevaluationondcsloratadinecitratecombined
3、withautohemotherapyinthetreatmentofautoimmuneurticaria[HJ2][HJ]MENGJinqiu,MENGAnding,JIANIluahui,HUANGYongtong,YANGShanjing(DepartmentofDermatology,AffiliatedSouthwestHospitalofYoujiangMedicalUniversityforNationalities?DPeople,sHospitalofBaise,Baise533000,China)[HJ2][HJ][
4、Abstract]ObjectiveToevaluateefficacyofdesloratadinecitratecombinedwithautohemotherapyinthetreatmentofautoimmuneurticaria.Methods218casesofchronicurticariapatientswithpositiveautologousserumskintest(ASST)wereselectedasstudysubjects.Allpatientswererandomlyclassifiedintoobse
5、rvationgroupone,observationgrouptwoandcontrolgroup.Thecontrolgroupweretreatedwithoraldesloratadinecitratetablets，theobservationgrouponeweregivenautohemotherapy,thatwastointramuscularlyinjectpatients9ownvenousbloodonceaweek,andtheobservationgrouptwoweregivenoraldesloratadi
6、necitratetabletsinthebasisofautohemotherapy.Allgroupsweretreatedfor8weeks.Then,changesofitchdegreeandwhealnumbers(UASevaluationand4gradeevaluationmethod）beforeandaftertreatmentwererecorded，andefficacyofthethreegroupswerecomparedandanalyzed.ResultsAfter8weeksoftreatment,to
7、talefficacyofthecontrolgroupwas74.29%，theobservationgrouponewas83.33%,andtheobservationgrouptwowas92.11%,improvementofclinicalsymptomsofthetwoobservationgroupswasallsignificantlybetterthanthatofthecontrolgroup,differencewasstatisticallysignificant（P<0.05）.Inaddition,there
8、wasstatisticallysignificantdifferenceincurativeeffectsbetweentheobservationgrouptwoandthecontrol
